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Purity :99%
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| Compound | AZD8186 | ||||
|---|---|---|---|---|---|
| CAS No. | 1627494-13-6 | Catalog No. | T0045 | Brand | |
| Purity | 99% | Packing | 1kg | Grade | |
| Lead Time | 14Day (s) | Origin | Loading Port | ||
AZD8186 is a potent and selective inhibitor of PI3K and PI3K with IC50 of 4 nM and 12 nM, respectively. Phase 1.
AZD8186 potently inhibits p-Akt in MDA-MB-468 cells sensitive to PI3K inhibition and Jeko B cells sensitive to PI3K inhibition with IC50 of 3 nM and 4 nM, respectively. AZD8186 shows preferred growth inhibition activity in most PTEN deficient cell lines with GI50 of <1 M.
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