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Purity :99%
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Purity :99%
CAS NO.: 1260141-27-2
Purity :99%
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Purity :99%
| Compound | Vonoprazan Fumarate | ||||
|---|---|---|---|---|---|
| CAS No. | 1260141-27-2 | Catalog No. | T0041 | Brand | |
| Purity | 99% | Packing | 1kg | Grade | |
| Lead Time | 14Day (s) | Origin | Loading Port | ||
| Soluble | DMSO > 10 mM |
|---|
Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.
TAK-438 is a pyrrole derivative with a chemical structure that is completely different from the P-CABs developed to date. TAK-438 inhibits gastric H+, K+-ATPase activity in a concentration-dependent manner. Under neutral conditions (pH 7.5), the inhibitory activity of TAK-438 is almost the same as that under weakly acidic conditions (pH 6.5). TAK-438 does not inhibit Na+, K+-ATPase activity even at concentration 500 times higher than their IC50 values against gastric H+,K+-ATPase activity. TAK-438 inhibits gastric H+, K+-ATPase in a K+-competitive manner with Ki of 3 nM.
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