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| Compound | 6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide | ||||
|---|---|---|---|---|---|
| CAS No. | 606143-89-9 | Catalog No. | T0016 | Brand | |
| Purity | 99% | Packing | 1kg | Grade | |
| Lead Time | 14Day (s) | Origin | Loading Port | ||
Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Phase 3.
ARRY-438162 (625 nM) inhibits in vitro osteoclast differentiation with IC50 of 39 nM. ARRY-438162 (10 M) inhibits in vitro osteoclast resorption with IC50 of 625 nM. ARRY-438162 (2 M) weakly affects osteoblast differentiation. ARRY-438162 is a recently disclosed potent and selective ATP non-competitive MEK1/2 inhibitor, inhibits pERK in cells with an IC50 of11 nM. MEK162 (1 M) combined with MK-2206 (2 M) completely reverses the resistance of RSK-expressing MCF7 cells.
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