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Compound | streptozocin | ||||
---|---|---|---|---|---|
CAS No. | 18883-66-4 | Catalog No. | C14194 | Brand | |
Purity | 99% | Packing | 1g | Grade | |
Lead Time | 3Day (s) | Origin | Loading Port |
Storage Condition | -20ºC |
---|---|
Appearance & Physical State | Pale yellow crystalline powder |
Refractive Index | 1.67 |
Density | 1.86 g/cm3 |
Melting Point | 115ºC (dec.) |
Streptozotocin CAS:18883-66-4
Molecular Formula: C8H15N3O7
Molecular Weight: 265.22
Description:Pale yellow crystalline powder
Assay (HPLC)>99%
Alternative Name: Streptozotocin; Streptozocin; Streptozotocin;U-9889;STZ;Estreptozocin;U 9889;NSC 37917;Zanosar;NSC 85998;N-(Methylnitrosocarbamoyl)--D-glucosamine
Chemical Name: 2-Deoxy-2-[[(methylnitrosoamino)car
Biological Activity:
Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic -cells in vivo.
Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals. It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA.DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.
CAS No : 18883-66-4
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