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ChemLeader Biomedical Co., Limited

ChemLeader Biomedical Co., Limited

Certified Store
Reagent Business
China Shanghai Pudong New Area
sales@medchemleader.com
021-58180488

Catalog No. : C14194

streptozocin

  • 18883-66-4
  • 1g
  • 99%
  • 3Day (s)
Packing :
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  • Product Details & Description

Product Info

Compound streptozocin
CAS No. 18883-66-4 Catalog No. C14194 Brand
Purity 99% Packing 1g Grade
Lead Time 3Day (s) Origin Loading Port

PropertiesMore

Storage Condition -20ºC
Appearance & Physical State Pale yellow crystalline powder
Refractive Index 1.67
Density 1.86 g/cm3
Melting Point 115ºC (dec.)

Description

Streptozocin;Streptozotocin

Streptozotocin CAS:18883-66-4  

Molecular  Formula: C8H15N3O7

Molecular  Weight: 265.22

Description:Pale yellow crystalline powder  
Assay (HPLC)>99%

Alternative Name: Streptozotocin; Streptozocin; Streptozotocin;U-9889;STZ;Estreptozocin;U 9889;NSC 37917;Zanosar;NSC  85998;N-(Methylnitrosocarbamoyl)--D-glucosamine

Chemical Name: 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose; 2-Desoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose;  2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose

Biological  Activity:

Antibiotic and antitumor agent. Alkylates DNA and  induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in  pancreatic -cells in vivo.

Streptozotocin (STZ)  is a glucosamine-nitrosourea which is  commonly used to induce experimental diabetes in animals. It specifically targets beta cells,  entering via the glucose  transporter GLUT2 and causing alkylation of DNA.DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals,  leading to the destruction of beta cells.The effectiveness of STZ depends on the level of GLUT2  expression, which in turn may be influenced by age, sex, strain, or  species.

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streptozocin

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18883-66-4

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