ChemLeader Biomedical Co., Limited

(-)-Epigallocatechin gallate (EGCG) CAS:989-51-5  

Molecular  Formula: C₂₂H₁₈O₁₁

Molecular  Weight: 458.38

Synonyms: (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol  3-(3,4,5-trihydroxybenzoate); (-)-Epigallocatechin gallate; (-)-Epigallocatechin  gallate 3-O-gallate

Appearance:White powder  
EGCG: >80%,90%,95%,98%

Origin of Extraction: Green tea

Specifications: 80%,90%,95%,98% etc.

Solubility: Easily soluble in  water

EGCG is a kind of component extracted from Chinese green tea. It is the  primary active and water-soluble component of green tea, which has the highest  content among the the tea catechins. It accounts for 9-13% of green tea in net  weight. By virtue of its peculiar stereochemical structure, EGCG possesses much  stronger anti-oxidant activities and plays an important role in preventing  cancer and cardiovascular diseases. In addition, it is potent as the reversal  agent of MDR (Multidrug Resistance). As such, it may improve the sensitivity of  cancer cells to chemotherapy drugs and reduce toxicity on the heart.

Biological  effects:
(-)-Epigallocatechin  gallate (egcg), an most potent antioxidant polyphenols of green tea, is  associated with antioxidant, antitumor and antimutagenic activities. The  antioxidant activity is at lest 100 times effective than vitamin C and 25  timeseffective than vitamin E at protecting cells and DNA from damage which are  believed to be linked to cancer, heart disease and other potentially fatal  illnesses. The biological benefits of EGCG are generally attributed to their  antioxidant activity to scavenge free radical oxygen.  

EGCG is the major component of the polyphenolic fraction of green tea. It  makes up about 10-50% of the total green tea catechins includeing  epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin  gallate(ECG), epicatechin(EC), gallocatechin gallate (GCG), catechin are major  catechin of green tea catechin. The antioxidant activity increased in the  following order: EC<ECG<EGC<EGCG.

Many studies indicate EGCG plays a role, which protects aganist free-radical  DNA damage, protects aganist the effects of ionizing radiation and ultraviolet  radiation, ;inhibits lipid peroxidation, decreases serum cholesterol levels,  LDL, VLDL and triglycerides, interferes with the binding of cancer-causing  agents to cellular DNA, helps to neutralize dietary carcinogens, works with  enzymes and other antioxidants in the intestine, liver and lungs to prevent the  activation of certain carcinogens before they damage DNA. As a free radicals  scavenger, EGCG combats the effects of pollution, sunlight and smoking, helps  skin from wrinkling and aging.

Safety:

Green tea  consumption of as much as 20 cups per day has not been assoiated with any  significant side effects. Acute studies reported the oral LD50 of EGCG in mice  was 2170mg/kg bw.

Application:

Medicine,  Health food, Food, Beverage, Cosmetics and Beverage, etc.