1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Skin sensitization, Category 1

Acute toxicity - Inhalation, Category 3

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H317 May cause an allergic skin reaction H331 Toxic if inhaled H350 May cause cancer H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P311 Call a POISON CENTER/doctor/… P308+P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Inhalation or ingestion causes bluish tint to fingernails, lips, and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Methylene blue, alone or in combination with oxygen, is indicated as treatment in nitrite-induced methemoglobinemia.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water, dry chemical, foam or carbon dioxide

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride and oxides of nitrogen may form in fires. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: P3 filter respirator for toxic particles and chemical protection suit. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Removal of chloroaniline from wastewater by electrochemical treatment is discussed.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and food and feedstuffs.Storage temperature: ambient.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stability during transport: stable.

10.3 Possibility of hazardous reactions

P-CHLOROANILINE is incompatible with oxidizing agents. Also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. Subject to exothermic decomposition during high-temperature distillation. Incompatible with nitrous acid.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Very vigorous reactions may occur with strong oxidants.

10.6 Hazardous decomposition products

When heated to decomposition it emit toxic fumes of /hydrogen chloride and nitrogen oxides/.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat male oral 200-480 mg/kg bw /Purity and vehicle unspecified/
• Inhalation: LC50 Rat (Crl:CD, male) inhalation 2340 mg PCA/cu m/4 hr (head-only exposure) /PCA vapor aerosol mixture: respirable fraction 57-95%/
• Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Group B2 Probable Human Carcinogen

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50 Lepomis macrochirus (Bluegil)l 2.4 mg/L/96 hr /Conditions of bioassay not specified in source examined
• Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea; intoxication, immobilization) 13 mg/L/24 hr (95% confidence interval: 5-32 mg/L)
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

THE METABOLISM OF 4-CHLOROANILINE BY ISOLATED CULTURES OF THE SOIL FUNGUS FUSARIUM OXYSPORUM SCHLECHT WAS STUDIED. 2-AMINO-5-CHLOROPHENOL WAS POSITIVELY IDENTIFIED AS METABOLITE OF 4-CHLOROANILINE IN THE ISOLATED SOIL FUNGUS CULTURES.

12.3 Bioaccumulative potential

The average BCFs in the whole body of carp exposed to 4-chloroaniline in flow-through experiments (25°C, 12 L/hr) for 24 to 336 hr at high (10.4 ug/L) and low (0.30 ug/L) exposure levels were 0.8 and 1.7, respectively(3). Excretion was rapid with depuration rates and half-lives of 0.16/hr and 4.3 hr, respectively(3). Therefore, 4-chloroaniline should not bioconcentrate in fish. Uptake was rapid in static tests (0.20 umol/L, 26°C) on zebrafish and a BCF of 8.1 was obtained for 24 hr exposure(4). Elimination was best described by a two compartment first order model(4). After 53 hr of depuration, the concn of 4-chloroaniline in the zebrafish declined to 12.0% of the steady state value. The log BCF in Golden orfe was <1.30 for 3 day exposure(1). The 24-hr log BCF in green alga was 3.08 (dry wt basis(2)) and 2.42 (wt weight basis(1)). A BCF of 13.4 was reported for guppy (Poecilia reticulata)(5). According to a classification scheme(6), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc for 5 Belgium soils ranged from 230-469(1). The adsorption isotherm was not linear and the exponent in the Freundlich adsorption isotherm averaged 0.70(1). The Koc for 5 German soils ranged from 96 to 1,530 with the Freundlich exponent ranging from 0.92 to 1.23(2). From adsorption studies on three soils with radically different organic carbon and clay contents, it was shown that the percent (14)C labeled 4-choloroaniline that was bound increased with the organic carbon content of the soil and decreased with its clay content(3). Stronger binding at low concns, particularly with the soil of low organic carbon content, suggests that there are a limited number of available binding sites on the soil(3). At the lower concn (5ppm), percent binding ranged from 46-78%(3). The Koc to colloidal organic matter in ground water was high, 5,550, suggesting that adsorption onto this microparticulate matter could effectively increase the solubility and leaching of 4-chloroaniline into landfill groundwater(4). According to a classification scheme(5), Koc values between 50-150 suggest that 4-chloroaniline is expected to have high mobility in soil, Koc values >500 to >5000 suggest 4-chloroaniline is expected to have low to no mobility in soil. Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(7,8), suggesting that mobility may be much lower in some soils(SRC). Adsorption of 4-chloroaniline by 5 soils was studied in the lab; adsorption decreased with the depth of the soil sample, due to decreased organic carbon(6). Adsorption coefficients of 4-chloroaniline and 4 other organic compounds for organic and inorganic materials and natural soils were determined(2). With few exceptions, the organic constituents of the soils were mainly responsible for their adsorption properties(2). Cellulose appeared to be a well-suited model adsorbent for simulating the relative adsorption behavior of the chemicals(2). The pKa of 4-chloroaniline is 3.98(9), indicating that this compound will primarily exist in its nonionic form in the environment.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.