---

Section I.Chemical Product and Company Identification
    Chemical Name 4-Chloronitrobenzene
    Portland OR
    Synonym        Benzene, 1-chloro-4-nitro- (CA INDEX NAME);    
    1-Chloro-4-nitrobenzene
    Chemical Formula        C6H4ClNO2    
    CAS Number        100-00-5    

---

Section II.        Composition and Information on Ingredients    
    CAS Number Percent (%)        TLV/PEL        Toxicology Data    
    Chemical Name
    4-Chloronitrobenzene        Min. 98.0 (GC) This chemical is classified as a Rat LD50 (oral) 420 mg/kg    
    100-00-5
    carcinogen. There is no        Rabbit LD50 (dermal) 3040 mg/kg    
    acceptable exposure limit for a Rat LD50 (intraperitoneal) 420
    carcinogen.        mg/kg    
    This compound is classified as
    a possible mutagen. There is
    no acceptable exposure limit for
    a mutagen.

---

Section III. Hazards Identification
    Acute Health Effects        Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.    
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
    eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Skin contact may result in sensitization. Always cover all exposed skin with an impermeable layer and use proper eye
    protection. A OSHA/MSHA approved dust and vapor respirator is required when working with this material.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    Chronic Health Effects        CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Tumorigenic effects.
    Mouse TD Oral 390 gm/kg for 78 weeks continuous
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Vascular - Tumors
    Liver - Tumors
    Mouse TDLo Oral 194 gm/kg for 78 weeks continuous
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Vascular - Tumors
    Liver - Tumors
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TCLo Inhalation 24 ppm for 6 hours, male 13 weeks prior to mating
    Toxic Effects:
    Paternal Effects - Spermatogenesis
    Mouse TDLo Oral 58 gm/kg, male 15 weeks prior to mating
    Toxic Effects:
    Effects on Newborn - Live birth index
    Effects on Newborn - Viability index
    Effects on Newborn - Growth statistics
    Mouse TDLo Oral 250 mg/kg, female multigenerations
    Toxic Effects:
    Specific Developmental Abnormalities - Blood and lymphatic system
    Specific Developmental Abnormalities - Hepatobiliary system
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
    many human organs.
    Continued on Next Page
    4-Chloronitrobenzene

---

Section IV.        First Aid Measures    
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15    
    minutes. Get medical attention.
    Skin Contact        In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing    
    and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
    Inhalation        If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or    
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    Ingestion        INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.    
    Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
    material was ingested; the absence of such signs, however, is not conclusive.

---

Section V.        Fire and Explosion Data    
    510°C (950°F)
    Flammability        May be combustible at high temperature.        Auto-Ignition    
    LOWER: 1.5% UPPER: 9.6%
    Flash Points        127°C (260.6°F)        Flammable Limits    
    Combustion Products        These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), halogenated compounds.    
    WARNING: Highly toxic HCl gas is produced during combustion.
    Fire Hazards
    Not available.
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media
    SMALL FIRE: Use DRY chemical powder.
    LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
    and Instructions
    Consult with local fire authorities before attempting large scale fire-fighting operations.

---

Section VI.        Accidental Release Measures    
    Spill Cleanup        Toxic material. Irritating material. This material is a skin sensitizer. Carcinogenic material. Possibly mutagenic material.    
    Environmentally hazardous material.
    Instructions
    Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
    vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all sources of ignition. Consult
    federal, state, and/or local authorities for assistance on disposal.

---

Section VII. Handling and Storage
    TOXIC. IRRITANT. SENSITIZER. CARCINOGEN. POSSIBLE MUTAGEN. ENVIRONMENTAL HAZARD. Keep locked up.
    Handling and Storage
    Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool
    Information
    place. Avoid excessive heat and light. DO NOT ingest. Do not breathe dust. Wear suitable protective clothing. If ingested,
    seek medical advice immediately and show the container or the label. Treat symptomatically and supportively.
    Always store away from incompatible compounds such as oxidizing agents, combustible materials, alkalis (bases).

---

Section VIII. Exposure Controls/Personal Protection
    Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
    Engineering Controls
    exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
    below the exposure limit.
    Personal Protection        Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid    
    inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
    product.
    Exposure Limits        This chemical is classified as a carcinogen. There is no acceptable exposure limit for a carcinogen.    
    This compound is classified as a possible mutagen. There is no acceptable exposure limit for a mutagen.

---

Section IX. Physical and Chemical Properties
    Solid. (Crystal ~ powder,        Solubility    
    Physical state @ 20°C        Freely soluble in boiling alcohol,    
    slightly pale yellow ~ yellow-green.)
    ether, carbon disulfide.
    Soluble in methanol, benzene.
    1.520 (water=1)
    Specific Gravity
    Sparingly soluble in cold alcohol.
    Insoluble in water (0.45g/L 20°C).
    Molecular Weight        157.55        Partition Coefficient        LOG Pow: 2.39    
    Boiling Point        242°C (467.6°F)        2 Pa (@ 30°C)    
    Vapor Pressure
    Melting Point        84°C (183.2°F)        Vapor Density        5.44 (Air = 1)    
    Not available.        Not available.    
    Refractive Index        Volatility    
    Critical Temperature        Not available.        Odor        Characteristic.    
    Not available.        Not available.    
    Viscosity        Taste    
    Continued on Next Page
    4-Chloronitrobenzene

---

Section X.        Stability and Reactivity Data    
    Stability    

---

This material is stable if stored under proper conditions. (See Section VII for instructions)    
    Conditions of Instability        Avoid excessive heat and light.    
    Incompatibilities
    Reactive with oxidizing agents, combustible materials, alkalis (bases).

---

Section XI. Toxicological Information
    CZ1050000
    RTECS Number
    Routes of Exposure        Eye Contact. Ingestion. Inhalation.    
    Rat LD50 (oral) 420 mg/kg
    Toxicity Data
    Rabbit LD50 (dermal) 3040 mg/kg
    Rat LD50 (intraperitoneal) 420 mg/kg
    Chronic Toxic Effects        CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Tumorigenic effects.
    Mouse TD Oral 390 gm/kg for 78 weeks continuous
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Vascular - Tumors
    Liver - Tumors
    Mouse TDLo Oral 194 gm/kg for 78 weeks continuous
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Vascular - Tumors
    Liver - Tumors
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TCLo Inhalation 24 ppm for 6 hours, male 13 weeks prior to mating
    Toxic Effects:
    Paternal Effects - Spermatogenesis
    Mouse TDLo Oral 58 gm/kg, male 15 weeks prior to mating
    Toxic Effects:
    Effects on Newborn - Live birth index
    Effects on Newborn - Viability index
    Effects on Newborn - Growth statistics
    Mouse TDLo Oral 250 mg/kg, female multigenerations
    Toxic Effects:
    Specific Developmental Abnormalities - Blood and lymphatic system
    Specific Developmental Abnormalities - Hepatobiliary system
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many
    human organs.
    Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
    Acute Toxic Effects
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
    is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Skin contact may result in sensitization. Always cover all exposed skin with an impermeable layer and use proper eye
    protection. A OSHA/MSHA approved dust and vapor respirator is required when working with this material.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

---

Section XII.        Ecological Information    
    Not available.
    Ecotoxicity
    Environmental Fate        1-Chloro-4-nitrobenzene's production and use as an intermediate in preparing dyes, agricultural and rubber chemicals, may    
    result in its release to the environment through various waste streams. If released to air, a vapor pressure of 0.022 mm Hg at
    25 deg C indicates 1-chloro-4-nitrobenzene will exist solely as a vapor in the atmosphere. Vapor-phase
    1-chloro-4-nitrobenzene will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the
    half-life for this reaction in air is estimated to be 94 days. Weak absorption of UV light greater than 290 nm by
    1-chloro-4-nitrobenzene indicates potential for photolysis by sunlight. If released to soil, 1-chloro-4-nitrobenzene is expected
    to have moderate mobility in soil based on an estimated Koc value of 310. Volatilization from dry soil surfaces may occur
    given a Henry's Law constant of 4.9X10-6 atm-cu m/mole. 1-Chloro-4-nitrobenzene is not expected to volatilize from dry soil
    surfaces based upon its vapor pressure. Screening tests using activated sludge, suggest biodegradation of
    1-chloro-4-nitrobenzene proceeds slowly in water and soil. If released into water, 1-chloro-4-nitrobenzene is expected to
    adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be
    an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model
    river and model lake are 152 hours and 73 days, respectively. Hydrolysis is not expected to be an important environmental
    fate process since this compound lacks functional groups that hydrolyze under environmental conditions. BCF values of
    5.8-20.9 measured in fish, suggests bioconcentration in aquatic organisms is low. Occupational exposure may occur through
    inhalation and dermal contact with this compound at workplaces where 1-chloro-4-nitrobenzene is produced or used.
    Continued on Next Page
    4-Chloronitrobenzene

---

Section XIII. Disposal Considerations
    Waste Disposal        Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a    
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state and local regulations when disposing of the substance.

---

Section XIV. Transport Information
    DOT CLASS 6.1: Toxic material
    DOT Classification
    PIN Number
    Proper Shipping Name        Chloronitrobenzenes, solid    
    Packing Group (PG)        II    
    DOT Pictograms

---

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.    
    (EPA)
    WHMIS Classification        CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).    
    CLASS D-2B: Material causing other toxic effects (TOXIC).
    (Canada)
    On DSL.
    EINECS Number (EEC) 202-809-6
    EEC Risk Statements        R23/24/25- Toxic by inhalation, in contact with skin and if swallowed.    
    R36/37/38- Irritating to eyes, respiratory system and skin.
    R43- May cause sensitization by skin contact.
    R45- May cause cancer.
    R46- May cause heritable genetic damage.
    R47- May cause birth defects.
    R51- Toxic to aquatic organisms.
    R53- May cause long-term adverse effects in the aquatic environment.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A