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| Compound | Iodotrimethylsilane | ||||
|---|---|---|---|---|---|
| CAS No. | 16029-98-4 | Catalog No. | XMZX-W5512 | Brand | |
| Purity | 99% | Packing | 25kg/DRUMS | Grade | |
| Lead Time | 3Day (s) | Origin | Loading Port | China,Xiamen,Siming District | |
| Boiling Point | 106ºC |
|---|---|
| Storage Condition | -20ºC |
| Appearance & Physical State | Clear very slight brown liquid. |
| Water Solubility | reacts |
| Flash Point | -31ºC |
| Refractive Index | 1.47-1.48 |
| Density | 1.406 |
| Melting Point | <0ºC |
| Vapor Pressure | 40.5mmHg at 25°C |
Uses Trimethylsilyliodide is a typical blocking agent in pharmaceutical manufacturing, widely used in the syntheses of drugs. It can protect or deprotect functional groups selectively, act as silane blocking agent.
Uses Iodotrimethylsilane is used for the introduction of trimethylsilyl group in organic synthesis. It is also useful for gas chromatography analysis by converting alcohol into a silyl ether derivative, thereby making it more volatile than the original molecule.
Uses Iodotrimethylsilane is an efficient reagent for ether, ester, carbamate, ketal, and lactone cleavage.
Uses Iodotrimethylsilane can be used as a versatile reagent for the mild dealkylation of ethers, carboxylic esters, lactones, carbamates, acetals, phosphonate and phosphate esters; cleavage of epoxides, cyclopropyl ketones; conversion of vinyl phosphates to vinyl iodides; neutral nucleophilic reagent for halogen exchange reactions, carbonyl and conjugate addition reactions; use as a trimethylsilylating agent for formation of enol ethers, silyl imino esters, and N-silylenamines, alkyl, alkenyl and alkynyl silanes; Lewis acid catalyst for acetal formation, α- alkoxymethylation of ketones, for reactions of acetals with silyl enol ethers and allylsilanes; reducing agent for epoxides, enediones, α-ketols, sulfoxides, and sulfonyl halides; dehydrating agent for oximes.
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