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| Compound | O-(5,6,7,8-tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate | ||||
|---|---|---|---|---|---|
| CAS No. | 88678-31-3 | Catalog No. | XMZX-W19366 | Brand | |
| Purity | 99% | Packing | 25kg/DRUMS | Grade | |
| Lead Time | 3Day (s) | Origin | Loading Port | China,Xiamen,Siming District | |
| Boiling Point | 462.5ºC at 760 mmHg |
|---|---|
| Storage Condition | -20ºC Freezer |
| Appearance & Physical State | white crystalline solid |
| Flash Point | 233.5ºC |
| Refractive Index | 1.641 |
| Density | 1.24g/cm3 |
| Melting Point | 98.5-99.5ºC |
Uses Broad-spectrum antifungal
Description Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6，7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.
Chemical Properties White Crystalline Solid
Originator Tosoh (Japan)
Uses A squalene epoxidase inhibitor. Used as an antifungal
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