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| Compound | Trimethylsilyl Cyanide | ||||
|---|---|---|---|---|---|
| CAS No. | 7677-24-9 | Catalog No. | XMZX-W17623 | Brand | |
| Purity | 99% | Packing | 25kg/DRUMS | Grade | |
| Lead Time | 3Day (s) | Origin | Loading Port | China,Xiamen,Siming District | |
| Boiling Point | 114-117ºC |
|---|---|
| Stability | Stable under normal temperatures and pressures. |
| Storage Condition | 0-6ºC |
| Appearance & Physical State | Clear, colorless liquid. |
| Water Solubility | reacts |
| Flash Point | 1ºC |
| Refractive Index | 1.388-1.392 |
| Density | 0.744 |
| Melting Point | 11ºC |
Uses Reacts with aldehydes and ketones to give cyanohydrin-TMS ethers which can be reduced to β-aminoethyl alcohols.
Trimethylsilyl cyanide (TMSCN) participates in carbonyl aminomethylation via α-silyloxy nitriles.
TMSCN can be used as a reagent in the:
Trimethylsilyl cyanide was used in the second step of an oxidative Michael addition of cyanide anion to Baylis–Hillman adducts. The importance of the addition of cyanide to α,β-unsaturated carbonyl derivatives is that the products can be converted into a variety of compounds including γ-aminobutyric acids. The reaction took place in a liquid ionic medium ([bmim]Br), which was reused several times without losing its activity. The β-cyano carbonyl compounds were obtained with high regioselectivity and yields (>79%).
Trimethylsilyl cyanide Synthesis
Cyanosilylation of carbonyl compounds using various catalysts.
Synthesis of α-aminonitriles by one-pot, three-component Strecker reaction of ketones with various amines using Brønsted acid catalyst.
Cyanation of aryl halides using palladium-complex as a catalyst.
Uses Trimethylsilyl Cyanide is used as a reagent in the synthesis of optically active cyanohydrins. Used in the preparation of Reissert compounds, which represent reactive polyamides. Toxic to humans.
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