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Compound | vorinostat | ||||
---|---|---|---|---|---|
CAS No. | 149647-78-9 | Catalog No. | XMZX-W4953 | Brand | |
Purity | 99% | Packing | 25kg/DRUMS | Grade | |
Lead Time | 3Day (s) | Origin | Loading Port | China,Xiamen,Siming District |
Appearance & Physical State | White Crystalline Solid |
---|---|
Refractive Index | 1.566 |
Density | 1.174 g/cm3 |
Melting Point | 161-162ºC |
Chemical Properties White Crystalline Solid
Originator Columbia University (US)
Uses A potent, selective, cell permeable histone deacetylase inhibitor (HDAC). Displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs). Induces differentiation in uman breast cancer cells.
Uses antineoplastic, histone deacetylase inhibitor
Uses Suberoylanilide Hydroxamic Acid is a potent, selective, cell permeable histone deacetylase inhibitor (HDAC). Suberoylanilide Hydroxamic Acid displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs). Suberoylanilide Hydroxamic Acid induces differentiation in uman breast cancer cells.
Uses A potent HDAC inhibitor; also causes cell cycle arrest at G1
Uses Vorinostat, a histone deacetylase (HDAC) inhibitor from Merck, was approved for the treatment of cutaneous T-cell lymphoma (CTCL), a type of non-Hodgkin’s lymphoma. Vorinostat was shown to inhibit HDAC1, HDAC2, HDAC3 and HDAC6 at nanomolar concentrations. HDAC inhibitors are potent differentiating agents toward a variety of neoplasms, including leukemia and breast and prostate cancers.
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