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| Compound | α-naphthoflavone | ||||
|---|---|---|---|---|---|
| CAS No. | 604-59-1 | Catalog No. | XMZX-W14780 | Brand | |
| Purity | 99% | Packing | 25kg/DRUMS | Grade | |
| Lead Time | 3Day (s) | Origin | Loading Port | ||
| Boiling Point | 460.9ºC at 760 mmHg |
|---|---|
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Storage Condition | 2-8ºC |
| Appearance & Physical State | yellow |
| Flash Point | 215.8ºC |
| Refractive Index | 1.695 |
| Density | 1.276 g/cm3 |
| Melting Point | 155-157ºC |
Chemical Properties yellow powder
Uses The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]
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