1.Identification
1.1 GHS Product identifier
| Product name | 2,6-dinitrotoluene |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 2,6-Dinitrotoluene |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. CBI |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
1.5 Emergency phone number
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 3
Acute toxicity - Dermal, Category 3
Acute toxicity - Inhalation, Category 3
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 1B
Specific target organ toxicity – repeated exposure, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3
Reproductive toxicity, Category 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H301 Toxic if swallowed H311 Toxic in contact with skin H331 Toxic if inhaled H341 Suspected of causing genetic defects H350 May cause cancer H373 May cause damage to organs through prolonged or repeated exposure H412 Harmful to aquatic life with long lasting effects H361f |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment. |
| Response | P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P311 Call a POISON CENTER/doctor/… P308+P313 IF exposed or concerned: Get medical advice/ attention. P314 Get medical advice/attention if you feel unwell. |
| Storage | P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2,6-dinitrotoluene | 2,6-dinitrotoluene | 606-20-2 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
INHALATION, INGESTION OR SKIN ABSORPTION: Headache, weakness, nausea or dizziness, cyanosis, drowsiness, shortness of breath and collapse. Can burn eyes and skin. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
In case of ingestion, induction of emesis is not recommended because of the potential for central nervous system depression. Gastric lavage and administration of activated charcoal may be considered soon after ingestion, provided airways are protected. /Dinitrotoluene/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, carbon dioxide, or dry chemical from protected location.
5.2 Specific hazards arising from the chemical
Special Hazards of Combustion Products: Emits toxic fumes of oxides of nitrogen Behavior in Fire: May explode when exposed to heat or flame. (USCG, 1999)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
1) REMOVE ALL IGNITION SOURCES. 2) VENTILATE AREA OF SPILL. 3) FOR SMALL QUANTITIES, SWEEP ONTO PAPER OR OTHER SUITABLE MATERIAL & BURN IN SUITABLE COMBUSTION CHAMBER WHICH ALLOWS BURNING IN UNCONFINED CONDITION & IS EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. LARGE QUANTITIES MAY BE RECLAIMED ... IF ... NOT PRACTICAL, DISSOLVE IN FUEL OIL & ATOMIZE IN SUITABLE COMBUSTION CHAMBER EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. /DINITROTOLUENE/
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong bases, food and feedstuffs, oxidants and strong reducing agents. Well closed. Keep in a well-ventilated room.Storage temperture: Ambient
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
NIOSH considers dinitrotoluene to be a potential occupational carcinogen. /Dinitrotoluene/
NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Dinitrotoluene/
Recommended Exposure Limit: 10 Hour Time-Weighted Average: 1.5 mg/cu m, skin. /Dinitrotoluene/
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | tan crystals |
|---|---|
| Colour | Yellow rhombic crystals |
| Odour | Slight odor |
| Melting point/ freezing point | 65ºC |
| Boiling point or initial boiling point and boiling range | 300ºC |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 130.6ºC |
| Auto-ignition temperature | no data available |
| Decomposition temperature | 285°C |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | In water:0.0182 g/100 mL |
| Partition coefficient n-octanol/water (log value) | log Kow = 2.10 |
| Vapour pressure | 0.018 mm Hg at 20°C |
| Density and/or relative density | 1.2833 |
| Relative vapour density | 6.28 (Relative to Air) |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
CombustibleDust explosion possible if in powder or granular form, mixed with air.2,6-DINITROTOLUENE is sensitive to heat. It may explode when exposed to heat or flame. It can be detonated only by a very strong initiator. This chemical is incompatible with strong oxidizers. It is also incompatible with caustics and metals such as tin and zinc. It may react with reducing agents. It will attack some forms of plastics, rubber and coatings.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
STABILITY: This chemical is stable under normal laboratory conditions. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions.REACTIVITY: This compound reacts with oxidizers, caustics, nitric acid, reducing materials and metals, such as zinc or tin. It may react violently in the presence of a base or when heated to the boiling point. It attacks some forms of plastics, rubbers and coatings.
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 177 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of ... 2,6-dinitrotoluene. There is sufficient evidence in experimental animals for the carcinogenicity of ... 2,6-dinitrotoluene. Overall evaluation: ... 2,6-Dinitrotoluene /is/ possibly carcinogenic to humans (Group 2B).
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50; Species: Pimephales promelas (Fathead Minnow) juvenile, length 2.4 cm, weight 0.28 g; Conditions: freshwater, static, 20.3 (19.5-22.0)°C, pH 7.6 (6.0-9.2), hardness 29.6 (12.0-43.0) mg/L CaCO3, alkalinity 31.0 (15.0-60.0) mg/L CaCO3, dissolved oxygen 7.2 (2.8-9.4) mg/L; Concentration: 18500 ug/L for 96 hr (95% confidence interval: 17200-20200 ug/L) /95-99% purity formulation
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea); Conditions: freshwater, renewal, 25°C, pH >7; Concentration: 20000 ug/L for 24 hr; Effect: behavior, equilibrium /formulation
- Toxicity to algae: EC50; Species: Scenedesmus subspicatus (Green Algae) exponential growth phase; Conditions: freshwater, static; 24°C, pH 8.0-9.3; Concentration: 16000 ug/L for 48 hr; Effect: population, decreased biomass /formulation
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: The biodegradability of 2,6-dinitrotoluene was tested in a static screening test using flasks that contained either 5 or 10 mg/L 2,6-dinitrotoluene, 5 mg/L yeast extract and settled domestic sewage as the inoculum. Subcultures were done every 7 days. The percent biodegradation by the original culture and first, second and third subcultures at an initial 2,6-dinitrotoluene concentration of 10 mg/L was: 57, 49, 35 and 13%, respectively(1). 2,6-Dinitrotoluene at an initial concentration of 10 ug/ml (10 mg/L) did not significantly degrade after 28 days incubation with raw municipal sewage(2). In another study, 2,6-dinitrotoluene inhibited biodegradation of municipal sewage at concentrations above 50 mg/L(3). In the same study, industrial seed degraded 50 mg/L 2,6-dinitrotoluene to 25 mg/L in 2 days, but after 7 days, 2,6-dinitrotoluene concentration remained at 25 mg/L. 2,6-Dinitrotoluene was easy to degrade according to results obtained by the "cultivation method" in which 98-100% and 83-100% degradation occurred in 3 days in river water and coastal sea water in Japan, respectively(7). 2,6-Dinitrotoluene was easily degraded by microorganisms in seawater, although the 2,6-isomer was the least readily degraded than all other dinitrotoluene isomers(4). This is consistent with the observation that the rate of reduction of nitro compound increases with increasing electron withdrawing power of groups in the para position(6). Degradation in river water was generally higher than in seawater(5). No degradation rates were given. The average percent biodegradation in eleven test runs of a pilot activated sludge plant was 57%(8).
12.3 Bioaccumulative potential
An estimated BCF of 11 was calculated for 2,6-dinitrotoluene(SRC), using a log Kow of 2.10(1) and a regression-derived equation(2). The BCF for dinitrotoluene (mixed isomers) has been measured to be low (BCF values of 0.6 to 21.2) in carp (Carprinus carpio)(3). According to a classification scheme(4), these BCF values suggest the potential for bioconcentration in aquatic organisms is low. An experimental log BCF of 2.44 (BCF of 275) (fat basis) was determined for 2,6-dinitrotoluene in the guppy (Poecilia reticulata) in a 3-day static test(5).
12.4 Mobility in soil
The Freundlich adsorption constant (exponent 1/n) for 2,6-dinitrotoluene in a Mississippi sandy loam soil (pH 5.6, organic carbon 0.94%) and a Texas sandy silt loam soil (pH 8.1, organic carbon 3.25%) was 0.014 (0.68) and 0.005 (0.61), respectively(1) which correspond to Koc values of 72 and 19, respectively(SRC). In a loamy sand soil containing an organic matter content of 8.5 g/kg, 2,6-dinitrotoluene had measured Kd adsorption coefficient 0.97 cu cm/g(2) that correspond to a Koc 197(SRC). According to a classification scheme(3), these Koc values indicate that 2,6-dinitrotoluene is expected to have very high to moderate mobility in soil. Field monitoring at a munition factory site in Melbourne Australia found that 2,6-dinitrotoluene migrated large distances in the subsurface soils(4). Leaching of 2,6-dinitrotoluene has been observed in soil column transport studies(5).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: UN3454 | IMDG: UN3454 | IATA: UN3454 |
14.2 UN Proper Shipping Name
| ADR/RID: DINITROTOLUENES, SOLID |
| IMDG: DINITROTOLUENES, SOLID |
| IATA: DINITROTOLUENES, SOLID |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 | IMDG: 6.1 | IATA: 6.1 |
14.4 Packing group, if applicable
| ADR/RID: II | IMDG: II | IATA: II |
14.5 Environmental hazards
| ADR/RID: no | IMDG: no | IATA: no |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 2,6-dinitrotoluene | 2,6-dinitrotoluene | 606-20-2 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 19, 2017 |
|---|---|
| Revision Date | Aug 19, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
