1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 4

Skin sensitization, Category 1

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

Reproductive toxicity, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H312 Harmful in contact with skin H317 May cause an allergic skin reaction H341 Suspected of causing genetic defects H350 May cause cancer H373 May cause damage to organs through prolonged or repeated exposure H411 Toxic to aquatic life with long lasting effects H361f
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P308+P313 IF exposed or concerned: Get medical advice/ attention. P314 Get medical advice/attention if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

In case of eye contact

Rinse with plenty of water (remove contact lenses if easily possible).

If swallowed

Rinse mouth.

4.2 Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, nose, throat; dermatitis; ataxia, tachycardia, nausea, vomiting, convulsions, respiratory depression; methemoglobinemia, cyanosis, headache, lassitude (weakness, exhaustion), dizziness, bluish skin; liver injury; [potential occupational carcinogen] Target Organs: Eyes, skin, respiratory system, blood, cardiovascular system, liver (NIOSH, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Irrigate eyes with water. Wash contaminated area of body with soap and water.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, foam, powder, carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic fumes are generated when heated. Behavior in Fire: Toxic gases are produced when heated to decomposition temperature. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Spillage Disposal. Personal protection: chemical protection suit including self-contained breathing apparatus. Do not let this chemical enter the environment. Do not wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Well closed. Separated from oxidants and acids. Separated from food and feedstuffs. Store in an area without drain or sewer access. Do NOT store or transport in containers made from aluminium or copper and its alloys. Provision to contain effluent from fire extinguishing.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers toluenediamine be a potential occupational carcinogen. NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Toluenediamine/

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Readily becomes oxidized in neutral or alkaline soln to form dark products

10.3 Possibility of hazardous reactions

If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. Dust explosion possible if in powder or granular form, mixed with air.2,4-TOLUENEDIAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts vigorously with oxidizing agents (USCG, 1999).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

STABILITY: This chemical is sensitive to air and moisture. It is sensitive to temperatures greater than 104 F. It is also sensitive to prolonged exposure to light. This compound readily becomes oxidized in neutral or alkaline solutions to form a dark product. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions.REACTIVITY: This compound may react with acids, acid chlorides, acid anhydrides, strong oxidizing agents and chloroformates. It is also incompatible with isocyanates.

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of nitrogen oxides.

11.Toxicological information

Acute toxicity

• Oral: LDLo Rat oral 500 mg/kg.
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.

Reproductive toxicity

In humans occupationally exposed to toluene-2,4-diamine, several studies did not report any statistically significant reproductive or developmental effects. Developmental and reproductive effects were observed in animals, including a significant decrease in the number of births and increases in maternal deaths, stillbirths, and resorptions.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Pimephales promelas (fathead minnow); Conditions: flow through bioassay with measured concentrations, 24.2°C, dissolved oxygen 6.5 mg/L, hardness 46.3 mg/L calcium carbonate, alkalinity 123 mg/L calcium carbonate, and pH 7.6; Concentration: 1420 mg/L for 96 hr
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr, Lake Langedam strain; Conditions: freshwater, static, 20°C, pH 7.8-8.0, hardness 250 mg/L CaCO3, dissolved oxygen 94-99%; Concentration: 12000 ug/L for 24 hr; Effect: intoxication, immobilization /98% purity
• Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green Alga) exponential growth phase; Conditions: freshwater, static, 25°C, pH 6.0-7.5; Concentration: 78.1 ug/L for 96 hr (95% confidence interval: 60-100.7 ug/L); Effect: decreased population abundance /formulation
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Toluene-2,4-diamine, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). A decline of 45% in the theoretical organic carbon of toluene-2,4-diamine was observed after 4 hr exposure to activated sludge in a fill and draw apparatus(2). When incubated with a synthetic batch activated sludge acclimated to the 2,4- and 2-6-isomers, diaminotoluenes, present at 300 mg/L, were 80% biodegraded in 4 days(3). Toluene-2,4-diamine, (ring-labeled), produced 35% 14-CO2 evolution in 375 days using a soil inoculum in the shake flask test(4). Adsorption to soil is expected to attenuate biodegradation(5). Using an inoculum from a munitions manufacturing wastewater treatment plant in Radford, VA, toluene-2,4-diamine, present at 500 mg/L, yielded 41.1 mg COD, with each 0.55 mM addition being consumed within 2-4 days(6).

12.3 Bioaccumulative potential

A BCF range of 1.9-3.3 was measured in fish for toluene-2,4-diamine, present at 1 mg/L, and orange-red killifish (Oryzias latipes) which were exposed over an 6-week period(1). According to a classification scheme(3), this BCF range suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using aerobic conditions with a Washington silt loam surface soil (21% sand; 60% silt; 19% clay; pH 5; 1.3% total organic carbon) from a farm field planted with a rotation of corn and soybeans near Bethehem, PA and a Freehold sandy loam soil (53% sand; 40% silt; 7% clay; pH 5.8; 1.6% total organic carbon) from the Rutgers Experimental Farm, Adelphia, NJ, the Koc of toluene-2,4-diamine were measured to be 1331 and 1346, respectively. Under anaerobic conditions, Koc values were 713 and 1054, respectively(1). According to a classification scheme(2), this estimated Koc value suggests that toluene-2,4-diamine is expected to have low mobility in soil. The estimated pKa of toluene-2,4-diamine is 5.35(3), indicating that this compound will exist partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(5,6), suggesting that mobility may be much lower in some soils(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.