1.Identification
1.1 GHS Product identifier
Product name | Clorofene |
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1.2 Other means of identification
Product number | - |
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Other names | o-Benzyl-p-Chlorophenol |
1.3 Recommended use of the chemical and restrictions on use
Identified uses | For industry use only. |
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Uses advised against | no data available |
1.4 Supplier's details
Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
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Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
Telephone | +86(21)64956998 |
Fax | +86(21)54365166 |
1.5 Emergency phone number
Emergency phone number | +86-400-6021-666 |
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Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Serious eye damage, Category 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements
Pictogram(s) | ![]() ![]() |
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Signal word | Danger |
Hazard statement(s) | H318 Causes serious eye damage H411 Toxic to aquatic life with long lasting effects |
Precautionary statement(s) | |
Prevention | P280 Wear protective gloves/protective clothing/eye protection/face protection. P273 Avoid release to the environment. |
Response | P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor/… P391 Collect spillage. |
Storage | none |
Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
---|---|---|---|---|
Clorofene | Clorofene | 120-32-1 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound in humans include drowsiness, loss of consciousness, irregular pulse and cyanosis. It may also cause irritation of the skin and mucous membranes. It is corrosive to the eyes, and extremely corrosive to the mouth and throat. Swallowing dusts or solids causes severe and rapid burning of the mouth, throat and digestive tract accompanied by severe pain, vomiting and collapse. It has also caused severe porphyrea cutanea tarda. ACUTE/CHRONIC HAZARDS: This compound is a highly toxic irritant. It is irritating to the skin and respiratory tract, and corrosive to the eyes. It is also extremely corrosive to the mouth and throat. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide, chlorine or hydrogen chloride, and other unidentified organic compounds in black smoke.
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Administer activated charcoal ... . Do not use emetics. Cover skin burns with dry, sterile dressings after decontamination ... . Maintain body temperature. /Phenols and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.
5.2 Specific hazards arising from the chemical
This chemical is combustible.
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state | Off white to pale yellow flake |
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Colour | White to light tan or pink flakes |
Odour | White to light tan or pink flakes |
Melting point/ freezing point | 207°C(lit.) |
Boiling point or initial boiling point and boiling range | 162°C/3.5mmHg(lit.) |
Flammability | no data available |
Lower and upper explosion limit / flammability limit | no data available |
Flash point | 84°C(lit.) |
Auto-ignition temperature | no data available |
Decomposition temperature | no data available |
pH | no data available |
Kinematic viscosity | no data available |
Solubility | less than 1 mg/mL at 16.11°C |
Partition coefficient n-octanol/water (log value) | log Kow = 3.6 |
Vapour pressure | 0.1 mm Hg at 20°C |
Density and/or relative density | 1.188 |
Relative vapour density | no data available |
Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
CombustibleORTHO-BENZYL-PARA-CHLOROPHENOL is incompatible with acids and oxidizing agents . Is sensitive to light. Stable at temperatures up to 25°C when protected from light, but storage at 60°C causes decomposition.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
no data available
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /hydrogen chloride/.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 1700 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group C Possible Human Carcinogen
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 Lepomis macrochirus (Bluegill) 0.33 ppm/96 hr (95% confidence limit: 0.2-0.4 ppm); static /formulated product
- Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea; intoxication, immobilization) 0.59 ppm/48 hr (95% confidence limit: 0.46-0.76 ppm); static /formulated product
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: Biodegradation rate constants and half-lives of 0.21 to 1.04/days and <1 to 3 days, respectively, were reported in river die away studies using unacclimated river water containing 0.1 mg/L o-benzyl-p-chlorophenol(1). The biodegradation half-life of o-benzyl-p-chlorophenol at an initial concentration of 0.5 mg/L was 1 to 2 days, in a sewage sludge(1). Activated sludge with an initial concentration of 0.5 mg/L o-benzyl-p-chlorophenol had a biodegradation rate constant of 3.88/days and a half life of 0.18 days as measured by DOC loss(1). Ultimate biodegradation to CO2 and H2O using acclimated sewage and 20-30 mg/L o-benzyl-p-chlorophenol, took slightly longer with a half-life of 7 to 23 days(1). o-Benzyl-p-chlorophenol undergoes rapid biodegradation after a short acclimation period in river water; o-benzyl-p-chlorophenol at a concentration of 0.1 mg/L was 78% degraded aerobically after 8 days; first re-spike (0.1 mg/L) on day 8 with 90% removal after 2 days; second re-spike of 0.1 mg/L on day 10 with 100% removal by day 13(2). o-Benzyl-p-chlorophenol, 0.5 mg/L, added to natural domestic sewage was substantially degraded within one day; re-spiked (1.0 mg/L) with nearly 100% removal within one day(2). Acclimated activated sludge mixed liquor in a semicontinuous activated sludge unit (o-benzyl-p-chlorophenol concentration, 2.0 mg/L) gave complete removal of DOC (dissolved organic carbon) in 24 hours. Sludge from a semicontinuous activated sludge unit was used as inoculum (o-benzyl-p-chlorophenol, 20 mg/L); there was a one week lag period followed by CO2 evolution at 60% of the theoretical within 27 days(2). CO2 evolution was used as a test method in this experiment to ensure that degradation was due to microbial action(2).
12.3 Bioaccumulative potential
A BCF value of 75 was measured for bluegill sunfish(1). Bluegill sunfish (Lepomis machrochirus) were exposed to 0.057 mg/L o-benzyl-p-chlorophenol for a period of 96 hours followed by a depuration period of 96 hours to determine the ability of the fish to metabolize and eliminate o-benzyl-p-chlorophenol. Depuration rate constants were from 4.67 to 6.94/days with a half-life of 0.14 days(1). The rate constant of o-benzyl-p-chlorophenol uptake in fish ranged from 11.8 to 13.8/days with a half-life of 0.06 days. According to a classification scheme(2), this BCF value suggests that bioconcentration in aquatic organisms is moderate(SRC).
12.4 Mobility in soil
An experimentally determined Koc of 2050 was obtained by equilibrating aqueous solutions of o-benzyl-p-chlorophenol (at concentrations ranging from 0.5 to 10 mg/L) with four different soils, with organic carbon contents ranging from 0.41 to 1.97%, and then analyzing both soil and water phases for o-benzyl-p-chlorophenol(1). According to a suggested classification scheme(2), this Koc value indicates that o-benzyl-p-chlorophenol is expected to have slight mobility in soil(SRC).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN3077 | IMDG: UN3077 | IATA: UN3077 |
14.2 UN Proper Shipping Name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. |
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. |
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. |
14.3 Transport hazard class(es)
ADR/RID: 9 | IMDG: 9 | IATA: 9 |
14.4 Packing group, if applicable
ADR/RID: III | IMDG: III | IATA: III |
14.5 Environmental hazards
ADR/RID: yes | IMDG: yes | IATA: yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name | Common names and synonyms | CAS number | EC number |
---|---|---|---|
Clorofene | Clorofene | 120-32-1 | none |
European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
EC Inventory | Listed. | ||
United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
Vietnam National Chemical Inventory | Not Listed. | ||
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
16.Other information
Information on revision
Creation Date | Aug 10, 2017 |
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Revision Date | Aug 10, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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