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SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Tetramethyl orthosilicate    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
    CAS-No.        : 681-84-5    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

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SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 3), H226
    Acute toxicity, Inhalation (Category 1), H330
    Skin irritation (Category 2), H315
    Serious eye damage (Category 1), H318
    Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    T+ Very toxic        R10, R26, R37/38, R41    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Danger    
    Hazard statement(s)
    H226        Flammable liquid and vapour.    
    H315        Causes skin irritation.    
    H318        Causes serious eye damage.    
    H330        Fatal if inhaled.    
    H335        May cause respiratory irritation.    
    Precautionary statement(s)
    P260        Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.    
    P280        Wear protective gloves/ eye protection/ face protection.    
    P284        Wear respiratory protection.    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    P310        Immediately call a POISON CENTER or doctor/ physician.    
    Supplemental Hazard        none    
    Statements
  Other hazards
    This substance/mixture contains no components considered to be either persistent, bioaccumulative and
    toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

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SECTION 3: Composition/information on ingredients
  Substances
    Synonyms        : Tetramethoxysilane    
    Formula        : C4H12O4Si    
    Molecular weight        : 152,22 g/mol    
    CAS-No.        : 681-84-5    
    EC-No.        : 211-656-4    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Tetramethyl orthosilicate
    CAS-No.        681-84-5        Flam. Liq. 3; Acute Tox. 1;        <= 100 %    
    EC-No.        211-656-4        Skin Irrit. 2; Eye Dam. 1;    
    STOT SE 3; H226, H315,
    H318, H330, H335
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Tetramethyl orthosilicate
    CAS-No.        681-84-5        T+, R10 - R26 - R37/38 - R41 <= 100 %    
    EC-No.        211-656-4    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

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SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    No data available

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SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, silicon oxides
  Advice for firefighters
    Wear self-contained breathing apparatus for firefighting if necessary.
  Further information
    Use water spray to cool unopened containers.

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SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove
    all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
    explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

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SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
    Store under inert gas. Moisture sensitive. Hydrolyses readily.
    Storage class (TRGS 510): Flammable liquids
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
    the product.
  Personal protective equipment
  Eye/face protection
    Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection
    tested and approved under appropriate government standards such as NIOSH (US) or EN
    166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: butyl-rubber
    Minimum layer thickness: 0,3 mm
    Break through time: 480 min
    Material tested:Butoject® (KCL 897 / Z677647, Size M)
    Splash contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,4 mm
    Break through time: 120 min
    Material tested:Camatril® (KCL 730 / Z677442, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The
    type of protective equipment must be selected according to the concentration and amount of the
    dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

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SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid    
    Colour: colourless
    b) Odour        aromatic    
    c) Odour Threshold        No data available    
    d) pH        No data available    
    e) Melting point/freezing        Melting point/range: -4 °C - lit.    
    point
    f) Initial boiling point and 121 - 122 °C - lit.
    boiling range
    g) Flash point        26 °C - closed cup    
    h) Evaporation rate        No data available    
    i) Flammability (solid, gas) No data available
    j) Upper/lower        Upper explosion limit: 23,8 %(V)    
    flammability or        Lower explosion limit: 0,88 %(V)    
    explosive limits
    k) Vapour pressure        18 hPa at 20 °C    
    l) Vapour density        5,26 - (Air = 1.0)    
    m) Relative density        1,023 g/mL at 25 °C    
    n) Water solubility        hydrolyses    
    o) Partition coefficient: n- No data available
    octanol/water
    p) Auto-ignition        No data available    
    temperature
    q) Decomposition        No data available    
    temperature
    r) Viscosity        No data available    
    s) Explosive properties        No data available    
    t) Oxidizing properties        No data available    
  Other safety information
    Relative vapour density 5,26 - (Air = 1.0)

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SECTION 10: Stability and reactivity
  Reactivity
    No data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    No data available
  Conditions to avoid
    Heat, flames and sparks.
  Incompatible materials
    Oxidizing agents, acids, Bases
  Hazardous decomposition products
    Other decomposition products - No data available
    In the event of fire: see section 5

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SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LC50 Inhalation - Rat - 4 h - 0,4 mg/l
    LD50 Dermal - Rabbit - 17.544 mg/kg
  Skin corrosion/irritation
    No data available
  Serious eye damage/eye irritation
    No data available
  Respiratory or skin sensitisation
    No data available
  Germ cell mutagenicity
    No data available
  Carcinogenicity
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    No data available
  Specific target organ toxicity - single exposure
    Inhalation - May cause respiratory irritation.
  Specific target organ toxicity - repeated exposure
    No data available
  Aspiration hazard
    No data available
  Additional Information
    RTECS: VV9800000
    Blindness, Effects due to ingestion may include:, Nausea, Vomiting, Gastrointestinal disturbance,
    Dizziness, Difficulty in breathing, Weakness, Drowsiness, Unconsciousness

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SECTION 12: Ecological information
  Toxicity
    No data available
  Persistence and degradability
    No data available
  Bioaccumulative potential
    No data available
  Mobility in soil
    No data available
  Results of PBT and vPvB assessment
    This substance/mixture contains no components considered to be either persistent, bioaccumulative and
    toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
  Other adverse effects
    No data available

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SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
    company.
  Contaminated packaging
    Dispose of as unused product.

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SECTION 14: Transport information
  UN number
    ADR/RID: 2606        IMDG: 2606        IATA: 2606    
  UN proper shipping name
    ADR/RID: METHYL ORTHOSILICATE
    IMDG: METHYL ORTHOSILICATE
    IATA:        Methyl orthosilicate    
    Passenger Aircraft: Not permitted for transport
    Cargo Aircraft: Not permitted for transport
  Transport hazard class(es)
    ADR/RID: 6.1 (3)        IMDG: 6.1 (3)        IATA: 6.1 (3)    
  Packaging group
    ADR/RID: I        IMDG: I        IATA: -    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    No data available

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SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    No data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

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SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    Eye Dam.        Serious eye damage    
    Flam. Liq.        Flammable liquids    
    H226        Flammable liquid and vapour.    
    H315        Causes skin irritation.    
    H318        Causes serious eye damage.    
    H330        Fatal if inhaled.    
    H335        May cause respiratory irritation.    
    Skin Irrit.        Skin irritation    
    STOT SE        Specific target organ toxicity - single exposure    
  Full text of R-phrases referred to under sections 2 and 3
    T+        Very toxic    
    R10        Flammable.    
    R26        Very toxic by inhalation.    
    R37/38        Irritating to respiratory system and skin.    
    R41        Risk of serious damage to eyes.    
  Further information
    Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
    only.
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.