1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 2

Acute toxicity - Dermal, Category 4

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed H312 Harmful in contact with skin H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P273 Avoid release to the environment.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P362+P364 Take off contaminated clothing and wash it before reuse. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . See Notes.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give a slurry of activated charcoal in water to drink. NO mouth-to-mouth artificial respiration. Refer immediately for medical attention.

4.2 Most important symptoms/effects, acute and delayed

Very toxic, probable oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. May be fatal if inhaled, swallowed, or absorbed through skin. Contact may cause burns to skin and eyes. (EPA, 1998)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

A 32 yr old male with acute coumaphos poisoning ... the organophosphate poisoning was successfully managed by artificial ventilation, an infusion of pralidoxime and intermittent atropine. ...[Moore PG, James OF; Postgrad Med J 57 (672): 660-62 (1981)] Full text: PMC2426093

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Extinguish with water, foam, carbon dioxide, or dry chemical.

5.2 Specific hazards arising from the chemical

When heated to decomposition, it emits very toxic fumes of sulfur oxides, phosphorus oxides, and chlorides. Incompatible with piperonyl butoxide. Stable in water. (EPA, 1998)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance and protective clothing. Do NOT wash away into sewer. Collect the spilled substance into containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Hydrolysis: This cmpd can be decomposed on heating with concentrated alkali. It is oxidized with nitric acid or other oxidizing agents to the phosphate analogue, coroxon. Dilute alkali (pH 8-12) causes an opening of the pyrone ring, which can be closed again by acidification to yield the original compound.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.Storage temperature: Ambient

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

It is combustible ...Organothiophosphates, such as COUMAPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. It reacts with strong oxidizing agents and alkaline materials.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong oxidizing agents

10.6 Hazardous decomposition products

Toxic & irritating oxides of sulfur & phosphorus may form in fire.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rabbit oral 80 mg/kg
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Not Likely to be Carcinogenic to Humans

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Salvelinus namaycush (lake trout) weight 2.1 g; Conditions: static lab bioassay, 12°C; Concentration: 593 ug/L for 96 hr (95% confidence limit: 416-846 ug/L) /Technical material, 95-97%
• Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna /(Water flea)/; Concentration: 1.0 ug/L for 48 hr /Conditions of bioassay not specified
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: In a biodegradability screening test using an activated sludge inoculum and 50 ug/L of radio-labeled test compound, only 0.9% of coumaphos was mineralized in 5 days(1). Coumaphos in dipping solutions can be effectively biodegraded by specially grown pure cultures(2). Degradation was slow in a sandy loam soil, half-life approximately 300 days(2). The half-life in a field test in which 300 ppm of coumaphos was incorporated into the upper 15 cm of silty loam soil was about 200 days(2). The major degradation products were chlorferon (3-chloro-4-methyl-7-hydroxycoumarin) and the oxygen analog(2). No degradation was noted in a microbially-active Drummer silty clay loam soil in 22 days(2). Coumaphos was degraded in 7 days in soil slurries using soil from six vat waste disposal pits in Texas(4). In similar experiments using (14)C ring-labeled coumaphos, 61% of the (14)C was recovered as (14)CO2 when radiolabeled coumaphos was added to soil slurries containing 1200 mg/L coumaphos; no loss of coumaphos nor production of (14)CO2 was observed when sodium azide was added to the soil slurries(3).

12.3 Bioaccumulative potential

A BCF of 110 was determined in Golden ide (Leuciscus idus melanotus) in a 3-day test(1). A BCF of 540 was determined in bluegill (Lepomis macrochirus) exposed for 28 days(2). According to a classification scheme(3), these BCFs suggest bioconcentration in aquatic organisms is high. The 24 hr bioaccumulation factor in algae (Chlorella fusca) is 470(1).

12.4 Mobility in soil

Koc values of 5778 to 21,120 were reported in 4 soil types(1). According to a classification scheme(2), this Koc value range suggests that coumaphos is expected to be immobile in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.