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Compound | 6-aminonicotinamide | ||||
---|---|---|---|---|---|
CAS No. | 329-89-5 | Catalog No. | 6-aminonicotinamide | Brand | CHUANGHAI |
Purity | 99% | Packing | 1kg/DRUMS | Grade | |
Lead Time | 1Day (s) | Origin | ChinaHebeiShijiazhuang | Loading Port | China,Shanghai,Huangpu |
Boiling Point | 381.6ºC at 760 mmHg |
---|---|
Appearance & Physical State | White crystalline solid |
Flash Point | 184.6ºC |
Refractive Index | 1.643 |
Density | 1.323 g/cm3 |
Melting Point | 245-248ºC |
Physical & Chemical Property:
6 - Aminonicotinamide (an) is a kind of metabolite resistance, can be used to suppress many cell system of NADPH - producingpentosephosphatepathway (PPP), making it more susceptible to oxidative stress Chemicalbook. 6-Aminonicotinamide is a competitive inhibitor of NADP+ -Dependentenzymetiotide-6-Phosphatedehydrogenase (G6PD) with a Ki value of 0.46μM.
Application:
-Aminonicotinamide(100nM;7days)causesasignificantdecreaseinthehumanAR+,hormone-sensitiveprostatecancercelllinesLNCaPandLAPC4,aswellastheCRPC-derivativeC4-2and22Rv1cellmodels.6-Aminonicotinamide(100nM±10nMR1881asindicatedfor3days)increasesbothbasal-andR1881-mediatedROSlevels,suggesting6-Aminonicotinamideisblockingthecells'antioxidantdefense.6-AminonicotinamidealsoincreasesROSlevelsinC4-2cells.
If you are interested, please feel free to contact us!
Contact:
Malia
HeBei ChuangHai Biotechnology Co.,Ltd
malia@chuanghaibio.com
Qiaoxi district ,shijiazhuang city,hebei, China.
WhatsApp/Wechat:+8619567966607
www.chuanghaibio.com
No. | Description | Update Time | Operation |
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1 | Company introduction | 2023/12/06 | Download |
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