CHUANG HAI BIOTECHNOLOGY CO.,LTD

Contact person: Sily Dong

Email: Sily@chuanghaibio.com

Tel:+8613131128733

WhatsApp/Telgram/Wechat:+8613131128733

Hebei Chuanghai Biotechnology Co.,Ltd

Website: www.chuanghaibio.com

Chinese name imidazole Chinese synonyms: oxaline; imidazole; glyoxaline; oxaline; metazoline; imidazole (standard); imidazole domestic 99+; imidazole CAS: 288-32-4 English name Imidazole English synonyms 1H- IMIDAZOLE;1,3-DIAZA-2,4-CYCLOPENTADIENE;1,3-DIAZOLE;LABOTEST-BBLTBB0013Chemicalbook44;IMIDAZOLEBUFFER;IMINAZOLE;IMIDAZOLE;GLYOXALINCAS No. 288-32-4 Molecular formula C3H4N2 Molecular weight 68.08EINECS No. 206-019-2 Related categories Analytical standards; biological buffers; ready-to-use solutions; pesticide intermediates; triazole fungicides; fungicide intermediates; imidazoles; pharmaceutical raw materials; basic raw materials; impurity reference standards

Physical properties Only imidazole derivatives exist in nature, but no free imidazole. Those precipitated from benzene are monoclinic prismatic colorless crystals. There is an ammonia smell. Relative molecular mass 68.08. Relative density 1.0303 (101/4℃). The melting point is 89~91℃, and the boiling point is 257℃, 165℃~168℃ (2.67×103Pa), and 138.2℃ (1.60×103Pa). Flash point 145℃. The refractive index is 1.4801 (101℃). Viscosity 2.696mPa·s (100℃). Slightly soluble in benzene and petroleum ether, soluble in ether, acetone, chloroform, pyridine, easily soluble in water (normal temperature 70) and ethanol. Shows weak alkalinity. Because a hydrogen bond is formed between the -NH- bond at position 1 and the -N= bond at position 3, the boiling point is higher. When the hydrogen at position 1 is replaced, hydrogen bonds cannot be formed and the boiling point decreases. It is thermally stable and hardly decomposes below 250°C (decomposition temperature 590°C). It is also stable to reducing and oxidizing agents, but can form stable salts with inorganic acids. It has certain aromatic properties and can be halogenated, nitrated, sulfonated and hydroxymethylated under the action of catalysts. And can be coupled with diazonium salt at the 2-position. In addition, since the =NH group (position 1) connects two double bonds, it is somewhat "acidic" and can be substituted by metal to form a salt. The nitrogen source at position 3 has a coordination effect on metal ions and can form chelates. Although it is difficult to be reduced, it can combine with protons to form a cationic and resonant structure, thus forming a stable form. The tautomers of the imidazole ring are very easy to change, so the isomers at the 4th and 5th positions are difficult to distinguish.

Main uses: Imidazole is slightly more basic than pyrazole and can generate stable salts, such as picrates and nitrates. One use of imidazole is in the purification of His-tagged proteins Chemicalbook in metal chelate affinity chromatography (IMAC). The tagged protein binds to the nickel ion medium in the bead holes on the surface of the chromatography column. Excess imidazole passes through the chromatography column, eluting the tagged protein coordinated with nickel to obtain high-purity target protein.

Chemical properties: colorless prismatic crystals, weakly alkaline. Easily soluble in water, ethanol, ether, chloroform, pyridine, slightly soluble in benzene, and insoluble in petroleum ether. Usage: Imidazole is an intermediate of the pesticide imazalil, prochloraz and other fungicides, and is also an intermediate of the pharmaceutical antifungal drugs clotrimazole, econazole, ketoconazole and clotrimazole. Used as raw materials and intermediates for organic synthesis, used in the preparation of drugs and pesticides, used as analytical reagents, and also used in organic synthesis.

Usage: Imidazole can be used as an epoxy resin curing agent to improve the bending, tensile, compression and other mechanical properties of products, improve the electrical properties of insulation, and improve the chemical properties of resistance to chemical agents. It is widely used in computers and electrical appliances; as a copper Anti-rust agent for printed circuit boards and integrated circuits; used as pharmaceutical raw materials for the manufacture of antifungal drugs, antifungal agents, hypoglycemia treatment drugs, artificial plasma, Chemicalbook trichomonas treatment drugs, bronchial asthma treatment drugs, anti-spot treatments Rash agents, etc.; used as raw materials for pesticides, synergists for boric acid preparations, and preparation of insecticides and fungicides; in addition, imidazole is also used as urea-formaldehyde resin curing agent, photographic drugs, adhesives, coatings, and rubber vulcanizers. , raw materials for antistatic agents, etc.; organic synthesis intermediates. Usage Pesticide intermediates: Fungicide intermediates: Triazole fungicides

Usage: Galvanizing brightener

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Contact person: Sily Dong

Email: Sily@chuanghaibio.com

Tel:+8613131128733

WhatsApp/Telgram/Wechat:+8613131128733

Hebei Chuanghai Biotechnology Co.,Ltd

Website: www.chuanghaibio.com