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Compound | gabapentin | ||||
---|---|---|---|---|---|
CAS No. | 60142-96-3 | Catalog No. | 262-076-3 | Brand | CHUANGHAI |
Purity | 99% | Packing | 25kg | Grade | |
Lead Time | 3Day (s) | Origin | ChinaHebeiShijiazhuang | Loading Port | China,Shanghai,Huangpu |
Boiling Point | 314.4ºC at 760 mmHg |
---|---|
Stability | Stable at normal temperatures and pressures. |
Storage Condition | Keep tightly closed. |
Appearance & Physical State | white to off-white crystalline powder |
Flash Point | 144ºC |
Refractive Index | 1.484 |
Density | 1.058 g/cm3 |
Melting Point | 162ºC |
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γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter that functions by binding to the GABA receptors located in the spinal cord. Gabapentin is a γ-aminobutyric acid (GABA) analogue that acts as an anticonvulsant with proven analgesic effects in various neuropathic pain syndromes such as Complex Regional Pain Syndrome type one (CRPS 1). It is also prescribed to multiple sclerosis patients to control dysesthesias and may be useful in reducing neuropathic pain caused by cancer and HIV infection. It does not bind to GABA receptors, does not influence neural uptake of GABA, and does not inhibit the GABA-metabolizing enzyme, GABA transaminase. Unlike GABA, which does not pass through the blood-brain barrier, gabapentin penetrates into the central nervous system and binds to the α2δ-type voltage-gated calcium channels. The mechanism for the analgesic and anticonvulsant effects of gabapentin are not known.
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