Dalian Handom Chemicals Co.,Ltd.

1. Product Name: Calcium L-5-Methyltetrahydrofolate

2. Alias: Levomefolate Calcium; L-Methylfolate calcium salt; Levomefolic acid; (6S)-5-Methyltetrahydrofolic acid; LMSR; N-(4-((((6S)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; L-5-MTHF-Ca; 5-MTHF

3. Molecular Formula:C20H27CaN7O6

4. Molecular Weight: 501.56

5. CAS No.: 151533-22-1

6. EINECS No.: 691-636-3

7.Melting Point:＞300℃

8. Description: The calcium salt of L-5-methyltetrahydrofolate belongs to the folic acid family vitamins(vitamin B9, folic acid), which is a coenzyme form of folic acid. l-5-methyltetrahydrofolate calcium(5-mthf), is the naturally occurring salt-forming methyl derivative form of folic acid, 5-mthf is also known as L-methylfolate, it is the most biologically active and functional form of folic acid form, which is more easily absorbed than regular folic acid.

9. Specifications:

Appearance: White to light yellow crystalline powder

Identification 1) HPLC: The retention time of the major peak in the chroma-togram of the sample solution corresponds to that of the reference standard in the assay test

2) IR: In accordance with standard atlas

3) Calcium: Conformance to Requirements

Particle Size: Not less than 80% pass through 80 mesh

Not more than 3% pass through 270 mesh

Crystal Type: C Crystal

Calcium L-5-Methyltetrahydrofolate: 95.0%-102.0%(On Dried Basis)

L-5-Methyltetrahydrofolate: Not less than 85.0%(On Dried Basis)

Chloride: Not more than 0.5%

D-5-Methylfolate: Not more than 1.0%

Boron: Not more than 50ug/g

Platinum: Not more than 10ug/g

Arsenic: Not more than 1.5ug/g

Cadmium: Not more than 0.5ug/g

Lead: Not more than 1.0ug/g

Mercury: Not more than 1.5ug/g

4-aminobenzoyl-glutamic acid: Not more than 0.5%

4a-Hydroxy-5-methyltetrahydrofolic acid: Not more than 1.0%

Tetrahydrofolic acid: Not more than 0.5%

7,8 dihydrofolic acid: Not more than 0.5%

Folic Acid: Not more than 0.5%

5,10-methyltetrahydrofolic acid: Not more than 0.5%

5-methyltetrahydropteroic acid: Not more than 0.5%

Dimethyltetrahydrofolic acid: Not more than 0.15%

Individual unknown impurity: Not more than 0.10%

Total impurities: Not more than 2.5%

Ethanol: Not more than 5000ppm

Acetone: Not more than 5000ppm

Isopropyl alcohol: Not more than 5000ppm

Water Content(K. Fischer): 6.0%-17.0%

Calcium(On the anhydrous and solvent-free basis): 7.0%-8.5%

Total Plate Count: Less than 1000CFU/g

Moulds & Yeasts: Less than 100CFU/g

Bile resistance of gram-negative bacteria: Less than 100CFU/g

E.coli: Not Detected/g

Staphylococcus aureus: Not Detected/g

Salmonella: Not Detected/10g

10. Packaging: Double PE bags, one Aluminum foil bag, Carton or customized containers.

11. Shelf Life: 24 months after manufacturing date.

12. Storage Condition: Stored in a cool and dry place, in a tight container.