Shanghai Banfu Technology Co., Ltd.

What is L-2-Aminobutanamidehydrochloride?

L-2-Aminobutanamidehydrochloride is a chemical usually used as the chemical reagent andintermediate, such as being the intermediate for Levetiracetam, a medicineresisting epilepsia and convulsions.

Levetiracetam,with the chemical name (S)-2-(2-Oxopyrrolidin-1-yl)butanamide, is currently theonly epilepsia resisting medicine that has been proven to combine with thesynaptin SV2A inside the presynaptic nerve terminal. It can restrain theabnormal electro-discharge in the epilepsia loop, and therefore block theseizures. It is used in the treatment of partial, secondary and generalepilepsia.

Thestructure of Levetiracetam is similar to that of Piracetam. It was manufacturedby UCB Pharmaceuticals Inc., a Belgium company. In April 2000, Levetiracetambecame available as a generic drug in the United States. Nowadays, it ismarketed in many countries as an internationally-recognized new generationbroad spectrum epilepsia resisting medicine.

Comparedwith most other epilepsia resisting medicine, Levetiracetam shows strongerefficacy in resisting epilepsia. Not only its therapeutic index is high, butalso its pharmacokinetics property is quite unique. Taken orally, Levetiracetamworks fast and is safe. The bioavailability is as high as 100%.

A recentstudy funded by AgeneBio, supported by a grant from the National Institutes ofHealth, and conducted by Johns Hopkins researchers found out that AGB101, alow-dose version of levetiracetam, works against the memory-robbing ailment,and therefore restores brain function as well as reverses memory loss in earlyAlzheimer's disease.

Preparationof L-2-Aminobutanamide hydrochloride

Comprisingreacting (S)-2-aminobutyric acid hydrochloride with thionyl chloride to form anintermediate, reacting the intermediate with ammonia to formL-2-Aminobutanamide hydrochloride.

Synthesisof Levetiracetam from L-2-Aminobutanamide hydrochloride

UsingL-2-Aminobutanamide hydrochloride as the chiral source, the resolution ofraceme could be avoided.

Afeasible industrialized preparation way for Levetiracetam 

Late RingClosure route

UsingL-2-Aminobutanamide hydrochloride as the starting raw material, comprisingreacting with SOCl2 and get acyl chloride, and then esterification reactingwith methanol or ethanol to get amino ester. Through the intermolecularnucleophilic substitution between amino ester and ethyl-4-bromo butyrate, getan intermediate that after separation and purification, and with the existenceof 2-Hydroxy Pyrimidine, get ( S)-PBM by closing loop. Then through theaminolysis reaction, convert the ester into acid amides and get Levetiracetam.

Storageof L-2-Aminobutanamide hydrochloride

L-2-Aminobutanamidehydrochloride should be kept at the temperature of 2-8C. 

The Advantages of BGT for L-2-Aminobutanamide hydrochloride production

Competitive price

We offer the best price on the market dueto our advanced process.

Higher purity

Our L-2-Aminobutanamide hydrochloride can reach as high as 99% chemical and optical purity (by HPLC), andis the highest assay that is commercially available. The common purity of L-2-Aminobutanamide hydrochloride on the market is less than 98% chemically and less than 96%optically.

Bulk stock

As L-2-Aminobutanamide hydrochloride is one of Banffs most important products, a large stock isavailable all year round.

Others

Safe production process, environmentalfriendly, sustainable development.