Shenzhen Ainingtai Technology Co., Ltd.

Chlorpheniramine factory direct

Chinese alias: melamine; chlorpheniramine; chlorpheniramine maleate; chlorhexidine; chlorpheniramine maleate;
English name: Chlorphenamine Maleate
English alias: chlorphenamine hydrogen maleate
CAS Number: 113-92-8
Chemical name: N,N-dimethyl--(4-chlorophenyl)-2-pyridinepropylamine maleate
Molecular Formula: C20H23ClN2O4
Molecular weight: 390.86
Content: 99%
Melting point: 130-135 C (lit.)
Storage condition: -20C Freezer
Water solubility: 1-5 g/100 mL at 21 oC

Chemical properties: White crystalline powder. 131-135C. Soluble in water, ethanol, chloroform, slightly soluble in ether, odorless, bitter taste.
Packing: 25 kg/barrel.
Uses: Used as anti-allergic drugs
Uses: The product anti-histamine effect than diphenhydramine and promethazine, the amount of small, side effects are light. For urticaria, vasodilator rhinitis, colds, asthma, rhinitis, contact dermatitis, but also for allergies caused by drugs and food, insect bites and motion sickness.
Uses: Antihistamines. Similar to chlorhexidine, bromophenylamine is also an antihistamine. Bromopyramide is also produced in a similar manner as chlorotrimetrazine, except that the starting material is replaced by a bromobenzene compound.

Production methods : from 2-chlorobenzyl pyridine derived by two-step condensation. In a dry reaction vessel, ammoniacal sodium and anhydrous toluene were added, heated to reflux, and 2-p-chlorobenzylpyridine and bromoacetaldehyde diethyl acetal were simultaneously added dropwise. After the addition, reflux reaction 8h. After cooling, the toluene solution was taken and the solid matter was dissolved in a small amount of water and extracted with toluene. The extract was combined with toluene, washed with water to neutrality, and toluene was recovered to give 3-p-chlorobenzene-3-(2-pyridyl)-propionaldehyde diethyl acetal. Mix it with DMF and add it to the reaction pot. Add a mixture of formic acid and water under stirring. The reaction was heated to 110-120C for 2 hours and 150-160C for 3 hours. After cooling, DMF was recovered under reduced pressure, diluted with heated water, and adjusted to pH 14 with an alkali solution. Then, the mixture was extracted with toluene, and the extract was washed with water to neutrality, toluene was recovered, and then distilled under reduced pressure. The 150-190 C. fraction was collected to obtain chlorotrimetidine.