Shenzhen Sendi Biotechnology Co., Ltd.

68291-97-4

Chinese name: zonisamide

Chinese Synonyms: azathiamine; zonisamide; 1- (1,2-benzoxazol-3-yl) methylsulfonamide; 1- (1,2-benzoxazol-3- Sulfonamide; 1,2-benzisoxazole-3-methanesulfonamide; and zonisamide

English name: Zonisamide

English Synonyms: BENZO [D] ISOXAZOL-3-YL-METHANESULFONAMIDE; 1,2-BENZISOXAZOLE-3-METHANESULFONAMIDE; ZON; ZONISAMIDE; 3- (sulfamoylmethyl) -1,2-benzisoxazole; ad-810; ci-912; exceglan

CAS number: 68291-97-4

Molecular formula: C8H8N2O3S

Molecular weight: 212.23

EINECS number: 200-659-6

Related Disorders: Anticonvulsant; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Neurochemicals; Pharmaceuticals; Sulfur & Selenium Compounds; Ion Channels; Zonegran; Small molecule inhibitors; Pharmaceutical raw materials; Nervous system drugs; Pharmaceutical raw materials; Bioactive small molecules

Overview Zonisamide, English name is Zonisamide, chemical name is 1,2-benzisoxazole-3-methanesulfonamide, is a new broad-spectrum antiepileptic drug developed by the Japanese big pharmaceutical company, epilepsy is pediatric nerve One of the common diseases of the system. About 50 million epilepsy patients worldwide, about 9 million patients with epilepsy, most of the onset in childhood. About 20% to 30% of children with epilepsy after two or more than two kinds of anti-epileptic drugs after formal treatment can not control the seizure, known as drug-refractory epilepsy or drug-resistant epilepsy. This product brings more hope for the treatment of drug-resistant epilepsy, has received great attention. Studies have shown that this product is effective for many types of epilepsy, including partial seizures of epilepsy or secondary systemic attacks, generalized tonic clonic seizures were effective. Clinically used for epileptic seizures, small attacks, localized attacks, status epilepticus and psychomotor attacks, side effects. For mania, Parkinson's disease also has a preventive effect, is also used for the treatment of neuropathic pain and migraine. It was first approved for listing in Japan in 1989, listed in the United States in 2000 and was approved for listing in Europe in 2005.

Chemical properties of white to light yellow crystalline or crystalline powder, odorless, bitter taste. Easily soluble in acetone, soluble in methanol, ethanol, ethyl acetate or acetic acid, slightly soluble in water, n-hexane, ether or chloroform. Melting point 160 ~ 163 ; mp 162 ~ 166 . Acute Toxicity LD50} Rat (mg / kg): 1892,2001 Oral; 1273,2569 Subcutaneous injection; 699,733 Intraperitoneal injection; 604,748 Intravenous injection.

Use for epileptic seizures, small attacks, localized attacks, status epilepticus, and psychomotor attacks.

Production Method 3-Bromomethyl) -1,2-benzoxazol (I) was stirred in methanol and aqueous sodium sulfite at 50 C for 4 h to give 1,2-benzisoxazole-3-methanesulfonic acid Sodium (II). And phosphorus oxychloride reaction into acid chloride, and then with ammonia to give zonisamide.