Shenzhen Sendi Biotechnology Co., Ltd.

Chinese name: prazosin hydrochloride

Chinese Synonyms: prazosin hydrochloride; prazosin hydrochloride (Wei Pisi, urea Ningping, pulse Ningping); 1- (4-amino-6,7-dimethoxy-2-quinazolinyl) - Mephedrine hydrochloride; prazosin hydrochloride; 1- (4-amino-6,7-dimethoxy-2-quinazoline Yl) -4- (2-furoyl) piperazine hydrochloride / prazosin hydrochloride; prazosin hydrochloride (standard); prazosin hydrochloride solution, 100 PPM

English name: Prazosin hydrochloride

English Synonyms: 4-Amino-2-pyroyl-6,7-dimetoxypiperazin-1-yl- chynazolina hydrochloride; (4-Amino-6,7-dimethoxy-quinazolin-2-yl) piperazin- 1 -yl] - 2- furyl methanone hydrochloride; Prazosin hydrochloride, 1- Prazosin Hydrochloride (500 mg); Prazosin hydrochlori; [4- (4-AMino-6,7-diMethoxy-2- quinazolinyl) -1-piperazinyl] -2-furanylMethanone Hydrochloride; 1- (4-AMino-6,7- diMethoxy-2-quinazolinyl) -4- (2-furanylcarbonxyl) piperazine Hydrochloride

CAS number: 19237-84-4

Molecular formula: C19H22ClN5O4

Molecular weight: 419.86

EINECS No. 242-903-4

Related Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Adrenoceptor; Adrenoceptors; Amines; Bases & Related Reagents; Heterocycles; Nucleotides; MINIPRESS; Cardiovascular and Cerebrovascular Research Materials; Pharmaceutical Intermediates; Small Molecules Inhibitors; Pharmaceutical Raw Materials; ; Organic raw materials; pyrimidine

Overview Prazosin hydrochloride (Prazosin Hydrochloride) is a selective antagonist of vascular synaptic 1 adrenergic receptor blockers, is a quinazoline derivatives, relaxation of vascular smooth muscle, the expansion of peripheral blood vessels, reducing peripheral blood vessels Resistance, lower blood pressure, no effect on the presynaptic 2 receptor, but can block the postsynaptic membrane 1, against norepinephrine, phenylephrine and epinephrine pressure response. Clinical mainly for the treatment of various levels of hypertension, chronic congestive heart failure and benign prostatic hyperplasia. The biggest advantage of prazosin hydrochloride is no significant adverse effect on metabolism, blood lipid metabolism have a good effect, with diabetes or renal insufficiency in patients with hypertension is particularly effective. And compared with other antihypertensive drugs has the following advantages:

1. Compared with other vasodilators such as hydralazine, it rarely causes tachycardia and does not increase renin secretion;

2. With clonidine, methyl dopa and other antihypertensive drugs, no central nervous system, will not cause depression, impotence, loss of libido and other side effects;

Prazosin does not affect renal function, renal blood flow and glomerular filtration rate had no effect. Studies have shown that prazosin single-use can be effective in the treatment of hypertension, in the application of other antihypertensive drugs and ineffective treatment or due to side effects can not be increased dose circumstances, plus prazosin can increase antihypertensive efficacy . Long-term use of prazosin in hypertensive patients, no significant changes in renal function. In hypertensive renal insufficiency, many antihypertensive drugs can reduce renal blood flow and increase nitrogen retention, but prazosin will not affect the renal blood flow, blood pressure in the process of nitrogen retention was reduced, This renal insufficiency of hypertension is a more ideal antihypertensive drugs.

In addition, prazosin in the treatment of refractory heart failure also has some applications and effects. Prazosin can selectively expand resistance blood vessels and volume of blood vessels, both dilation of arteries, but also the expansion of venous blood can be balanced to reduce the heart of patients with severe heart failure before and after the load, improve cardiac pump function, worthy of clinical promotion.

Use For light, moderate hypertension, and -blockers or diuretics combined, better antihypertensive effect. As a second-line drugs, often in the first-line drug treatment is not satisfied or combined; for the treatment of moderate to severe chronic congestive heart failure and myocardial infarction heart failure, refractory heart failure also effective. Can be used to treat ergotamine excess.

An overview of prazosin hydrochloride, pharmacological effects, uses, adverse reactions, drug interactions are caused by.