1.Identification
1.1 GHS Product identifier
| Product name | 1,1-dimethylhydrazine |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | Hydrazine, 1,1-dimethyl- |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. 1,1-Dimethylhydrazine is primarily used as a high-energy fuel in military applications, as a rocket propellant and fuel for thrusters, and small electrical power generating units. 1,1-Dimethylhydrazine is also used in the manufacture of a plant growth regulator, in chemical synthesis, in photographic chemicals, as a stabilizer for fuel additives, and as an absorbent for acid gases. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
1.5 Emergency phone number
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Flammable liquids, Category 2
Acute toxicity - Oral, Category 3
Skin corrosion, Category 1B
Acute toxicity - Inhalation, Category 3
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |      |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H225 Highly flammable liquid and vapour H301 Toxic if swallowed H314 Causes severe skin burns and eye damage H331 Toxic if inhaled H350 May cause cancer H411 Toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment. |
| Response | P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P310 Immediately call a POISON CENTER/doctor/… P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P311 Call a POISON CENTER/doctor/… P308+P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage. |
| Storage | P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 1,1-dimethylhydrazine | 1,1-dimethylhydrazine | 57-14-7 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Half-upright position. Refer immediately for medical attention.
In case of skin contact
First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .
In case of eye contact
Rinse with plenty of water (remove contact lenses if easily possible).
If swallowed
Rinse mouth. Rest. Do NOT induce vomiting. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayed
This compound exhibits high acute toxicity as a result of exposure by all routes. Death or permanent injury may result after very short exposure to small quantities. Chronic exposure may cause pneumonia, liver damage, and kidney damage. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Specific treatment for exposure consists of thorough washing of all exposed skin areas with soap and water, copious irrigation of the eyes, and prompt removal of the patient from the source of exposure. /Hydrazines/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.
5.2 Specific hazards arising from the chemical
Vapor may explode if ignited in an enclosed area. Vapors may travel to a source of ignition and flashback. Runoff to sewer may create fire or explosion hazard. When it decomposes, 1,1-dimethylhydrazine gives off toxic nitrogen compound fumes. Dissolves, swells, and disintegrates many plastics. Dangerous when exposed to heat, flame, or oxidizers. Hazardous polymerization may not occur. (EPA, 1998)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable non-plastic containers. Do NOT absorb in saw-dust or other combustible absorbents. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Activated carbon, polyurethane foam and polypropylene fibers are the most advantageous agents for cleanup of 1,1-dimethylhydrazine. Also Amberlite XAD resins and Dowex 50WX8 or Amberlite IRA 900 may be used.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Fireproof. Provision to contain effluent from fire extinguishing. Separated from strong oxidants and strong acids. Dry. Well closed. Keep in a well-ventilated room. Do NOT store or transport in containers made from plastic. Store in an area without drain or sewer access.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
NIOSH considers 1,1-dimethylhydrazine to be a potential occupational carcinogen.
Recommended Exposure Limit: 2-Hr Ceiling Value: 0.06 ppm (0.15 mg/cu m).
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | Ferric arsenate is a green or brown powder. |
|---|---|
| Colour | CLEAR, COLORLESS LIQUID |
| Odour | Characteristic ammonia like fishy odor of aliphatic hydrazines |
| Melting point/ freezing point | -57.2ºC |
| Boiling point or initial boiling point and boiling range | 62-64ºC (753 mmHg) |
| Flammability | Class IB Flammable Liquid: Fl.P. below 22.78°C and BP at or above 37.78°C.Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | Lower 2% by vol; Upper 95% by vol |
| Flash point | -18ºC |
| Auto-ignition temperature | 248.89°C |
| Decomposition temperature | no data available |
| pH | STRONGLY ALKALINE LIQ |
| Kinematic viscosity | 0.492 millipascal second @ 25°C |
| Solubility | In water:miscible |
| Partition coefficient n-octanol/water (log value) | log Kow = -1.19 /Estimated/ |
| Vapour pressure | 103 mm Hg ( 20 °C) |
| Density and/or relative density | 0.785 |
| Relative vapour density | 1.94 (vs air) |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Solution stored in dark and cold are relatively stable in absence of oxidants
10.3 Possibility of hazardous reactions
It is flammable over a wide range of vapor air concentrations.The vapour is heavier than air and may travel along the ground; distant ignition possible.1,1-DIMETHYLHYDRAZINE is a powerful reducing agent. Ignition can occur on contact with oxidizing agents such hydrogen peroxide and fuming nitric acid [Haz. Chem. Data(1966)]. Also reacts as a base to neutralize acids in exothermic reactions.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Contact of dicyanofurazan, or its N-oxide (dicyanofuroxan), with ... dimethylhydrazine ... is instantaneously explosive.
10.6 Hazardous decomposition products
When heated to decomp it emits highly toxic fumes of /nitrogen oxides/.
11.Toxicological information
Acute toxicity
- Oral: LD50 Mouse oral 265 mg/kg /from table/
- Inhalation: LC50 Rat inhalation 252 ppm/4 hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group B2 Probable Human Carcinogen
Reproductive toxicity
No information is available on the reproductive or developmental effects of 1,1-dimethylhydrazine in humans. Sperm abnormalities and decreased sperm counts were observed in animals injected with 1,1-dimethylhydrazine. Birth defects were not observed in the offspring of animals exposed intraperitoneally to 1,1-dimethylhydrazine.
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 Pimephales promelas (Fathead minnow, 30 day old) 7.85 mg/L/96 hr (confidence limit: 7.16-8.62 mg/L); flow-through, 24.5°C, 7.4 mg/L dissolved O2, hardness 46.4 mg CaCO3/L, alkalinity 42.8 mg CaCO3/L
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
Contaminated wastewater from the NASA Kennedy Space station was studied in batch cultures and trickle bed reactors to monitor the degradation rates of hydrazine containing rocket fuels(1,2). The half-life of structurally similar methylhydrazine in batch cultures (Rhodococcus B30 or Achromobacter sp.) and trickle bed reactors was about 2.5 and 12 days, respectively(1). Biodegradation may be a significant removal process at low concentrations in soils or ambient waters, but at higher concentrations hydrazines are toxic to microorganisms(2). Concentrations of hydrazine and 1,1-dimethylhydrazine that reduced bacterial metabolism by 50% ranged from 14.6 to 145 mg/L and from 19.2 to 9,060 mg/L, respectively(3).
12.3 Bioaccumulative potential
An estimated BCF value of 3 was calculated for 1,1-dimethylhydrazine(SRC), using an estimated log Kow of -1.19(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Of the initial amount of 1,1-dimethylhydrazine in cleaned sand (100% sand), Vandenburg Air Force Base (VAFB) soil (99.1% sand, 0.4% clay, pH 6.1), organic soil (96.1% sand, 1% clay, 1% carbon, pH 6.4), and clay (69.3% sand, 27.95% clay, pH 3.7), 5%, 20%, 15%, and 30% was adsorbed, respectively. Passage of 2 liters of distilled, deionized water at 5 ml/min through columns containing sand, VAFB soil, organic soil and clay (10% clay soil plus 90% pure sand) in equilibrium with 10 ml of a 0.1 v/v solution of 1,1-dimethylhydrazine resulted in 99.9%, 42.5%, 21.9%, and 7.2% recovery of this compound, respectively(1). As the hydrazines are all very basic chemicals, adsorption to acidic, clay soils is expected(1).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: UN1163 | IMDG: UN1163 | IATA: UN1163 |
14.2 UN Proper Shipping Name
| ADR/RID: DIMETHYLHYDRAZINE, UNSYMMETRICAL |
| IMDG: DIMETHYLHYDRAZINE, UNSYMMETRICAL |
| IATA: DIMETHYLHYDRAZINE, UNSYMMETRICAL |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 | IMDG: 6.1 | IATA: 6.1 |
14.4 Packing group, if applicable
| ADR/RID: I | IMDG: I | IATA: I |
14.5 Environmental hazards
| ADR/RID: yes | IMDG: yes | IATA: yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 1,1-dimethylhydrazine | 1,1-dimethylhydrazine | 57-14-7 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 17, 2017 |
|---|---|
| Revision Date | Aug 17, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
