RTI 177

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: RTI 177
CAS No.: 171236-00-3 Formula: C23H23ClN2O Molecular Weight: 378.89500
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Edit: RTI 177

CAS No.:
171236-00-3
Formula:
C23H23ClN2O
Molecular Weight: 378.89500

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Overview
Description
Basic Info
Properties

Description

RTI(-4229)-177 (2β-(3-phenylisoxazol-5-yl)-3β-(4-chlorophenyl)tropane, β-CPPIT) is a synthetic stimulant drug from the phenyltropane family, which acts as a DRI with micromolar affinity for the SERT. RTI-177 has an unusually long duration of action of 20 hours or more, substantially longer than the related compound RTI-336 from which it differs in molecular structure only by the absence of a p-methyl group.
"the nonselective monoamine transporter inhibitor RTI-126 and the DAT-selective inhibitors RTI-150 and RTI-336 both had a faster rate of onset (30 min) and a short duration of action (4h). In contrast, the nonselective monoamine transporter inhibitor RTI-112 had a slower rate of onset (30–60 min) and a longer duration of action (10h). The DAT-selective inhibitors RTI-171 and RTI-177 also had slower rates of onset (30–120 min), but RTI-171 had a short duration of action (2.5 h) while RTI-177 had a very long duration of action (20 h)."

Basic Info

Chemical Name	RTI 177
Synonyms	(1R,2S,3S,5S)-3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl-isoxazol-5-yl)-8-aza-bicyclo[3.2.1]octane; 3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)tropane; β-CPPIT;
CAS No.	171236-00-3
Molecular Formula	C23H23ClN2O
Molecular Weight	378.89500
PSA	29.27000
LogP	5.66680