Telomestatin

Edit: Telomestatin

CAS No.:
265114-54-3
Formula:
C26H14N8O7S
Molecular Weight: 582.50400

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Overview
Description
Basic Info
Properties
MSDS
Spectrum

Description

Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of the cancer cells. It was first isolated from the bacteria Streptomyces anulatus. Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.

Basic Info

Chemical Name	Telomestatin
Synonyms	(1R)-4,8-Dimethyl-3,7,11,15,19,23,27-heptaoxa-31-thia-33,34,35,36,37,38,39,40-octaazanonacyclo[28.2.1.12,5.16,9.110,13.114,17.118,21.122,25.126,29]tetraconta-2(40),4,6(39),8,10(38),12,14 (37),16,18(36),20,22(35),24,26(34),28,30(33)-pentadecaene; (1<sup>2</sup>Z,2<sup>2</sup>Z,3<sup>2</sup>Z,4<sup>2</sup>Z,5<sup>2</sup>Z,6<sup>2</sup>Z,7<sup>2</sup>Z,8<sup>2</sup>Z)-6<sup>5</sup>,7<sup>5</sup>-dimethyl-8<sup>4</sup>,8<sup>5</sup>-dihydro-1(2,4),2,3,4,5,6,7(4,2)-heptaoxazola-8(2,4)-thiazolacyclooctaphane; SOT-095; (R,12Z,22Z,32Z,42Z,52Z,62Z,72Z,82Z)-65,75-dimethyl-84,85-dihydro-1(2,4),2,3,4,5,6,7(4,2)-heptaoxazola-8(2,4)-thiazolacyclooctaphane;
CAS No.	265114-54-3
Molecular Formula	C26H14N8O7S
Molecular Weight	582.50400
PSA	219.87000
LogP	5.20510

Properties

Appearance & Physical State	Solid powder
Soluble	Soluble in DMSO

MSDS

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SDS 1.0 Expand: SDS 1.0
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Spectrum

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1H NMR : PredictExpand: NMR Spectrum 1H NMR : Predict
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265114-54-3

C26H14N8O7S

Description

Basic Info

Chemical Name

Synonyms

CAS No.

Molecular Formula

Molecular Weight

PSA

LogP

Properties

Appearance & Physical State

Soluble

MSDS

SDS 1.0

SDS 1.0

Spectrum

NMR Spectrum 1H NMR : Predict

Hangzhou J&H Chemical Co., Ltd.

American Custom Chemicals Corporation

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