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SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : HEPES    
    REACH No.        : 01-2120054645-54-XXXX    
    CAS-No.        : 7365-45-9    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

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SECTION 2: Hazards identification
  Classification of the substance or mixture
    Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
    This substance is not classified as dangerous according to Directive 67/548/EEC.
  Label elements
    The product does not need to be labelled in accordance with EC directives or respective national laws.
  Other hazards
    This substance/mixture contains no components considered to be either persistent, bioaccumulative and
    toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

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SECTION 3: Composition/information on ingredients
  Substances
    Synonyms        : 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid    
    Formula        : C8H18N2O4S    
    Molecular weight        : 238,30 g/mol    
    CAS-No.        : 7365-45-9    
    EC-No.        : 230-907-9    
    Registration number        : 01-2120054645-54-XXXX    
    No components need to be disclosed according to the applicable regulations.

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SECTION 4: First aid measures
  Description of first aid measures
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration.
  In case of skin contact
    Wash off with soap and plenty of water.
  In case of eye contact
    Flush eyes with water as a precaution.
  If swallowed
    Never give anything by mouth to an unconscious person. Rinse mouth with water.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    No data available

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SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, Nitrogen oxides (NOx), Sulphur oxides
  Advice for firefighters
    Wear self-contained breathing apparatus for firefighting if necessary.
  Further information
    No data available

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SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Avoid dust formation. Avoid breathing vapours, mist or gas.
    For personal protection see section 8.
  Environmental precautions
    No special environmental precautions required.
  Methods and materials for containment and cleaning up
    Sweep up and shovel. Keep in suitable, closed containers for disposal.
  Reference to other sections
    For disposal see section 13.

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SECTION 7: Handling and storage
  Precautions for safe handling
    Provide appropriate exhaust ventilation at places where dust is formed.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
    Storage class (TRGS 510): Non Combustible Solids
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    General industrial hygiene practice.
  Personal protective equipment
  Eye/face protection
    Use equipment for eye protection tested and approved under appropriate government standards
    such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
  Body Protection
    Choose body protection in relation to its type, to the concentration and amount of dangerous
    substances, and to the specific work-place., The type of protective equipment must be selected
    according to the concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    Respiratory protection is not required. Where protection from nuisance levels of dusts are desired,
    use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and
    approved under appropriate government standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    No special environmental precautions required.

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SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: Crystalline powder    
    Colour: colourless
    b) Odour        No data available    
    c) Odour Threshold        No data available    
    d) pH        5,0 - 6,5 at 238 g/l at 25 °C    
    e) Melting point/freezing        Melting point/range: 212,6 °C - Decomposes before melting.    
    point
    f) Initial boiling point and Decomposes below the boiling point.
    boiling range
    g) Flash point        No data available    
    h) Evaporation rate        No data available    
    i) Flammability (solid, gas) The product is not flammable. - Flammability (solids)
    j) Upper/lower        No data available    
    flammability or
    explosive limits
    k) Vapour pressure        No data available    
    l) Vapour density        No data available    
    m) Relative density        1,439 g/cm3 at 20 °C    
    n) Water solubility        703,6 g/l at 20 °C - OECD Test Guideline 105    
    o) Partition coefficient: n- log Pow: < -3,85
    octanol/water
    p) Auto-ignition        does not ignite    
    temperature
    q) Decomposition        No data available    
    temperature
    r) Viscosity        No data available    
    s) Explosive properties        Not explosive    
    t) Oxidizing properties        The substance or mixture is not classified as oxidizing.    
  Other safety information
    Surface tension        63,98 mN/m at 20 °C    

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SECTION 10: Stability and reactivity
  Reactivity
    No data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    No data available
  Conditions to avoid
    No data available
  Incompatible materials
    Strong oxidizing agents
  Hazardous decomposition products
    Other decomposition products - No data available
    In the event of fire: see section 5

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SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Dermal - Rat - > 2.000 mg/kg
    (OECD Test Guideline 402)
  Skin corrosion/irritation
    Skin - Rabbit
    Result: No skin irritation
    (OECD Test Guideline 404)
  Serious eye damage/eye irritation
    Eyes - Rabbit
    Result: No eye irritation
    (OECD Test Guideline 405)
  Respiratory or skin sensitisation
    Maximisation Test (GPMT) - Guinea pig
    Did not cause sensitisation on laboratory animals.
  Germ cell mutagenicity
    in vitro assay
    Result: negative
    Lymphoma Mutation Assay
    Chromosome aberration test in vitro
    Result: negative
    Result: Not mutagenic in Ames Test.
  Carcinogenicity
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    Did not show teratogenic effects in animal experiments.
  Specific target organ toxicity - single exposure
    The substance or mixture is not classified as specific target organ toxicant, single exposure.
  Specific target organ toxicity - repeated exposure
    The substance or mixture is not classified as specific target organ toxicant, repeated exposure.
  Aspiration hazard
    No aspiration toxicity classification
  Additional Information
    Repeated dose toxicity - Rat - Oral - 28 d - No observed adverse effect level - 1.000 mg/kg
    RTECS: TL6809000

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SECTION 12: Ecological information
  Toxicity
    Toxicity to fish        LC50 - Brachydanio rerio (zebrafish) - > 100 mg/l - 96 h    
    (OECD Test Guideline 203)
    Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h
    other aquatic
    invertebrates
    Toxicity to algae        static test EC50 - Pseudokirchneriella subcapitata (green algae) - > 100 mg/l -    
    72 h
    (OECD Test Guideline 201)
    NOEC - Pseudokirchneriella subcapitata (green algae) - 100 mg/l - 72 h
    (OECD Test Guideline 201)
    Toxicity to bacteria        EC50 - Sludge Treatment - > 1.000 mg/l - 3 h    
    (OECD Test Guideline 209)
  Persistence and degradability
    Biodegradability        Result: - According to the results of tests of biodegradability this product is not    
    readily biodegradable.
    (OECD Test Guideline 301D)
  Bioaccumulative potential
    No bioaccumulation is to be expected (log Pow <= 4).
  Mobility in soil
    No data available
  Results of PBT and vPvB assessment
    This substance/mixture contains no components considered to be either persistent, bioaccumulative and
    toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
  Other adverse effects
    No data available

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SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Offer surplus and non-recyclable solutions to a licensed disposal company.
  Contaminated packaging
    Dispose of as unused product.

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SECTION 14: Transport information
  UN number
    ADR/RID: -        IMDG: -        IATA: -    
  UN proper shipping name
    ADR/RID: Not dangerous goods
    IMDG: Not dangerous goods
    IATA:        Not dangerous goods    
  Transport hazard class(es)
    ADR/RID: -        IMDG: -        IATA: -    
  Packaging group
    ADR/RID: -        IMDG: -        IATA: -    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    No data available

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SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    No data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

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SECTION 16: Other information
  Further information
    Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
    only.
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.